The Group
Dirk Trauner


Discovery of NVP-BYL719 a Potent and Selective Phosphatidylinositol-3 kinase Alpha Inhibitor Selected for Clinical Evaluation

Furet, P.; Guagnano, V.; Fairhurst, R. A.; Imbach-Weese, P.; Bruce, I.; Knapp, M.; Fritsch, C.; Blasco, F.; Blanz, J.; Aichholz, R.; Hamon, J.; Fabbro, D.; Caravatti, G. Bioorg. Med. Chem. Lett. 2013, 23, 3741–3748.

Total Synthesis of (−)-Crinipellin A

Kang, T.; Song, S. B.; Kim, W.; Kim, B. G.; Lee, H. J. Am. Chem. Soc. 2014, 136, 10274–10276

Synthesis of Eupalinilide E, a Promoter of Human Hematopoietic Stem and Progenitor Cell Expansion

T. C. Johnson, M. R. Chin, T. Han, J. P. Shen, T. Rana, D. Siegel.  J. Am. Chem. Soc. 2016, 138, 6068−6073

Total Synthesis of (−)-Himalensine A

Shi, H.; Michaelides, I. N.; Darses, B.; Jakubec, P.; Nguyen, Q. N. N.; Paton, R. S.; Dixon, D. J. J. Am. Chem. Soc. 2017, 139, 17755–17758.

Total Synthesis of (+)-Haperforin G

Zhang, W.; Zhang, Z.; Tang, J.-C.; Che, J.-T.; Zhang, H.-Y.; Chen, J.-H.; Yang, Z. J. Am. Chem. Soc. 2020, 142, 19487–19492

Total Synthesis of Liangshanone

Huang, H.-X.; Mi, F.; Li, C.; He, H.; Wang, F.-P.; Liu, X.-Y.; Qin, Y. Angew. Chem. Int. Ed. 2020, 59, 1-7.

Scalable Synthesis of Bryostatin 1 and Analogs, Adjuvant Leads Against Latent HIV

Wender, P. A.; Hardman, C. T.; Ho, S.; Jeffreys, M. S.; Maclaren, J. K.; Quiroz, R. V.; Ryckbosch S. M.; Shimizu, A. J.; Sloane, J. L.; Stevens, M. C. Science, 2017, 358, 218-223.

Enantioselective Total Synthesis of the Diterpenes Kempene‐2, Kempene‐1, and 3‐epi‐Kempene‐1 from the Defense Secretion of Higher Termites

Schubert, M.; Metz, P. Angew. Chem. Int. Ed. 2011, 50, 2954–2956.

Synthesis of Streptolydigin, a Potent Bacterial RNA Polymerase Inhibitor

Pronin, S. V.; Kozmin, S. A. J. Am. Chem. Soc. 2010, 132, 14394−14396.

Total Synthesis of Tagetitoxin

He, C.; Chu, H.; Stratton, T. P.; Kossler, D.; Eberle, K. J.; Flood, D. T.; Baran, P. S. J. Am. Chem. Soc. 2020, 142, 13683–13688.

Asymmetric Total Synthesis of Cyclocitrinol

Liu, J.; Wu, J.; Fan, J.-H.; Yan, X.; Mei, G.; Li, C.-C.; J. Am. Chem. Soc. 2018, 140, 5365–5369.

Total Synthesis of (–)-Nakadomarin A

Bonazzi, S.; Cheng, B.; Wzorek, J. S.; Evans, D. A. J. Am. Chem. Soc. 2013, 135, 9338–9341.

Total Synthesis of (±)-Chloranthalactone A

Yue, G.; Yang, L.; Yuan, C.; Jiang, X.; Liu, B.; Org. Lett. 2011, 13, 5460–5408.

Total Syntheses of Dibromophakellstatin and Dibromoagelaspongin

Feldman, K.S.; Skoumbourdis, A. P.; Org. Lett. 2005, 7, 929–931;

Feldman, K. S.; Fodor, M. D.; J. Am. Chem. Soc. 2008, 130, 14964–14965.

Total Synthesis of Talatisamine

Kamakura, D.; Todoroki, H.; Urabe, D.; Hagiwara, K.; Inoue, M.; Angew. Chem. Int. Ed. 2020, 59, 479–486.

Nineteen-Step Total Synthesis of (+)-Phorbol

Kawamura, S.; Chu, H.; Felding, J.; Baran, P. S.; Nature 2016, 532, 90-93

Total Synthesis and Structural Revision of Callipeltoside C

Carpenter, J.; Northrup A. B.; Chung, D.; Wiener, J. J. M.; Kim, S.-G.; MacMillan, D. W. C.; Angew. Chem. Int. Ed. 2008, 47, 3568–3572.

Total Syntheses of (–)-Deoxoapodine, (–)-Kopsifoline D and (–)-Beninine

Zhou, Y.-G.; Wong, H. N. C.; Peng, X.-S. J. Org. Chem. 2020, 85, 967–976.

Total Synthesis of Echinopines A and B: Exploiting a Bioinspired Late-Stage Intramolecular Cyclopropanation

Peixoto, P. A.; Richard, J. A.; Severin, R.; Chen, D. Y. K. Org. Lett. 2011, 13, 5724–5727.

Total Syntheses of (–)-Conidiogenone B, (–)-Conidiogenone, and (–)-Conidiogenol

Xu, B.; Xun, W.; Su, S.; Zhai, H.; Angew. Chem. Int. Ed. 2020, 59, early view.

A General Strategy to Elisabethane Diterpenes: Stereocontrolled Synthesis of Elisapterosin B via Oxidative Cyclization of an Elisabethin Precursor

Waizumi, N.; Stankovic, A. R.; Rawal, V. H. J. Am. Chem. Soc. 2003, 125, 13022–13023.

Synthesis of Anhydroryanodol

Du, K.; Kier, M. J.; Stempel, Z. D.; Jeso, V.; Rheingold, A. L.; Micalizio, G. C. J. Am. Chem. Soc. 2020, ASAP.

Asymmetric Total Synthesis of (+)-Waihoensene

Qu, Y.; Wang, Z.; Zhang, Z.; Zhang, W.; Huang, J.; Yang, Z. J. Am. Chem. Soc. 2020, 142, 6511–6515.

Spiroacetal Formation through Telescoped Cycloaddition and Carbon–Hydrogen Bond Functionalization: Total Synthesis of Bistramide A

Han X.; Floreancig P.E. Angew. Chem. Int. Ed. 2014, 53, 11075–11078.

Total Synthesis of Bryostatin 3

Trost, B.M.; Wang, Y.; Buckl, A. K.; Huang, Z.; Nguyen, M.H.; Kuzmina, O.; Science 2020, 368, 1007–1011.

An Enantiospecific Route to (+)- and (–)-Chrysanthemum Dicarboxylic Acids

Fitzsimmons, B. J.; Fraser-Reid, B.; Tetrahedron 1984, 40, 1279–1287.

Total Synthesis of (+)‐ and (±)‐Hosieine A

Huang, Y.; Kong, K.; Wood, J. L. Angew. Chem. Int. Ed. 2018, 57, 7664–7667.

The Total Synthesis of (–)-Scabrolide A

Hafeman, N. J.;  Loskot, S. A.;  Reimann, C. E.;  Pritchett, B. P.;  Virgil, S. C.;  Stoltz, B. M.; J. Am. Chem. Soc. 2020, 142, 8585–8590.

Catalytic Asymmetric Total Synthesis of Exiguolide

Oka K.; Fuchi S.; Komine, K.; Fukuda, H.; Hatakeyama, S.; Ishihara, J. Chem. Eur. J. 2020, accepted manuscript

Total Synthesis of (−)-Sinulariadiolide. A Transannular Approach

Meng, Z.; Fürstner, A.; J. Am. Chem. Soc. 2019, 141, 805–809.

Asymmetric Total Synthesis of Mycoleptodiscin A

Zhou, S.; Chen, H.; Luo, Y.; Zhang, W.; Li, A.; Angew. Chem. Int. Ed. 2015, 54, 6878–6882.

Total Synthesis of (+)-Haplophytine

Ueda, H.; Sato. H.; Matsumoto, K.; Sugimoto, K.; Fukuyama, T.; Tokuyama, H.; Angew. Chem. Int. Ed. 2009, 48, 7600–7603

Total Synthesis of (–)-Merochlorin A

Brandstätter, M.; Freis, M.; Huwyler, N.; Carreira, E. M. Angew. Chem. Int. Ed.2019, 58, 2490–2494.

Total Synthesis of (–)-Pavidolide B: A Ring Contraction Strategy

Rao, R.; Hu, J.; Xuan, J.; Ding, H.; J. Org. Chem. 2019, 84, 9385–9392.

Component-based Syntheses of Trioxacarcin A

Švenda, J.; Hill, N.; Myers, A. G.; Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 6709–671; [link]

Magauer, T.; Smaltz, D. J.; Myers, A. G.; Nat. Chem. 2013, 5, 886–893. [link]

Total Synthesis of (–)-Batrachotoxinin A: A Local-Desymmetrization Approach

Guo, Y.; Guo, Z.; Lu, J.-T.; Fang, R.; Chen, S.-C.; Luo T.; J. Am. Chem. Soc. 2020, 142, 3675–3679.

Total Synthesis of (–)-Allosecurinine

Leduc, A. B.; Kerr, M. A.; Angew. Chem. Int. Ed. 2008, 47, 7945–7948.

Divergent Synthesis of Antiviral Diterpenes Wickerols A and B

Deng, J.;  Ning, Y.;  Tian, H.; Gui, J.; J. Am. Chem. Soc. 2020, 142, 4690–4695.

A 16-Step Synthesis of the Isoryanodane Diterpene (+)-Perseanol

Han, A; Tao, Y.; Reisman, S. E.; Nature 2019, 573, 563–567.

Diastereoselective Total Synthesis of (±)-Schindilactone A

Xiao, Q.; Ren, W.-W.; Chen, Z.-X.; Sun, T.-W.; Li, Y.; Ye, Q.-D.; Gong, J.-X.; Meng, F.-K.; You, L.; Liu, Y.-F.; Zhao, M.-Z.; Xu, L.-M.; Shan, Z.-H.; Shi, Y.; Tang, Y.-F.; Chen, J.-H.; Yang, Z.; Angew. Chem. Int. Ed. 2011, 50, 7373–7377.

Total Synthesis of (−)-Oridonin: An Interrupted Nazarov Approach

L. Kong, F. Su, H. Yu, Z. Jiang, Y. Lu, and T. Luo, J. Am. Chem. Soc. 2019, 141, 20048–20052.

Total Synthesis of Solanoeclepin A

Tanino, K.; Takahashi, M.; Tomata, Y.; Tokura, H.; Uehara, T.; Narabu, T.; Miyashita, M. Nat. Chem. 2011, 3, 484–488.

Synthesis of Myrocin G, the Putative Active Form of the Myrocin Antitumor Antibiotics

Economou, C.; Tomanik, M.; Herzon, S. B. J. Am. Chem. Soc. 2018, 140, 16058−16061.

Total Synthesis of Jatrophatrione

L. A. Paquette, J. Yang, Y. O. Long J. Am. Chem. Soc. 2002, 124, 6542–6543.

Total Synthesis of the Sesquiterpenoid Periconianone A Based on a Postulated Biogenesis

Liffert, R.; Linden, A.; Gademann, K. J. Am. Chem. Soc. 2017, 139, 16096–16099.

Total Synthesis of (+)‐Daphmanidin E

Weiss, M. E.; Carreira, E. M Angew. Chem. Int. Ed. 2011, 50, 11501–11505.

Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold

Basarab, G. S.; Brassil, P.; Doig, P.; Galullo, V.; Haimes, H. B.; Kern, G.; Kutschke, A. McNulty, J.; Schuck, V. J. A.; Stone, G.; Gowravaram, M. J. Med. Chem. 2014, 57, 9078–9095.

Total Synthesis of Hyperforin

Ting, C. P.; Maimone, T. J. Am. Chem. Soc. 2015, 137, 10516-10519.

A 15-Step Synthesis of (+)-Ryanodol

Chuang, K. V.; Xu, C.; Reisman, S. E. Science 2016, 353, 912-915.

Total Synthesis of Isomalabaricane Triterpenoids

Boyko, Y. D.; Huck, C. J.; Sarlah, D. J. Am. Chem. Soc. 2019, 141, 14131-14135.

Total Synthesis of Viridin and Viridiol

Ji, Y Xin, Z. He, H. and Gao, S. J. Am. Chem. Soc. 2019, 141, 16208-16212.

Total Synthesis of the Diterpenoid Alkaloid Arcutinidine Using a Strategy Inspired by Chemical Network Analysis

K. R. Owens, S. V. McCowen, K. A. Blackford, S. Ueno, Y. Hirooka, M. Weber, R. Sarpong, J. Am. Chem. Soc.2019, 141, 13713–13717.

Asymmetric Total Synthesis of (–)-Vinigrol

L. Min, X. Lin, and C.-C. Li, J. Am. Chem. Soc. 2019, 141, 15773-15778.

Calyciphylline B-Type Alkaloids: Total Syntheses of (–)-Daphlongamine H and (–)-Isodaphlongamine H

Hugelshofer, C. L.; Palani, V.; Sarpong, R. J. Am. Chem. Soc. 2019, 141, 8431−8435.

Total Synthesis of (+)-Halichlorine: An Inhibitor of VCAM-1 Expression

Trauner, D; Schwarz J. B.; Danishefsky, S. J. Angew. Chem. Int. Ed. 1999, 38, 3542-3545.

Enantioselective Total Synthesis of (−)-Caldaphnidine O via a Radical Cyclization Cascade

Guo, L.-D.; Hu, J.; Zhang, Y.; Tu, W.; Zhang, Y.; Pu, F.; Xu, J. J. Am. Chem. Soc. 2019, 141, 13043−13048.

A Concise Total Synthesis of (–)-Himalensine A

Chen, Y.; Hu, J.; Guo, L.-D.; Zhong, W.; Ning, C.; Xu, J. Angew. Chem. Int. Ed. 2019, 58, 7390 –7394

Enantioselective Total Syntheses of Pallambins A-D

Zhang, X.; Cai, X.; Huang, B.; Guo, L.; Gao, Z.; Jia, Y. Angew. Chem. Int. Ed. 2019, 58, 13380-13384.

Isolation, Synthesis, and Bioactivity Studies of Phomactin Terpenoids

Y. Kuroda, K. J. Nicacio, I. A. da Silva-Jr, P. R. Leger, S. Chang, J. R. Gubiani, V. M. Deflon, N. Nagashima, A. Rode, K. Blackford, A. G. Ferreira, L. D. Sette, D. E. Williams, R. J. Andersen, S. Jancar, R. G. S. Berlinck, R. Sarpong, Nat. Chem. 2018, 10, 938-945.

Convergent, Enantioselective Synthesis of (+)-Guanacastepene E

Shipe, D. W.; Sorense, E. J. J. Am. Chem. Soc. 2006, 128, 7025–7035.

Total Synthesis of (-)-Vindorosine

W. Chen, X.-D. Yang, W.-Y. Tan, X.-Y. Zhang, X.-L. Liao, H. Zhang Angew. Chem. Int. Ed. 2017, 56, 12327–12331.

Total Syntheses of Rhodomolleins XX and XXII

Yu, K.; Yang, Z-N.; Liu, C-H.; Wu, S-Q.; Hong, X.; Zhao, X-L.; Ding, H. Angew. Chem. Int. Ed. 2019, 58, 8556-8560.

Enantioselective Total Synthesis of (+)-Flavisiamine F via Late-Stage Visible-Light-Induced Photochemical Cyclization

X. Tong, B. Shi , K. Liang, Q. Liu , C. Xia Angew. Chem. Int. Ed. 2019, 58, 5443–5446.

Total Synthesis of 1-Hydroxytaxinine

Imamura, Y.; Yoshioka, S.; Nagatomo, M.; Inoue, M. Angew. Chem. Int. ed. 2019, 58, 12159-12163.

Total Synthesis and Isolation of Citrinalin and Cyclopiamine Congeners

E. V. Mercado-Marin, P. Garcia-Reynaga, S. Romminger, E. F. Pimenta, D. K. Romney, M. W. Lodewyk, D. E. Williams, R. J. Andersen, S. J. Miller, D. J. Tantillo, R. G. S. Berlinck, R. Sarpong Nature 2014, 509, 318-324.

Chemoenzymatic Total Synthesis of ent-Oxycodone: Fourth generation

Makarova, M.; Endoma-Arias, M. A. A.; Dela Paz, H. E.; Simionescu, R.; Hudlicky, T. J. Am. Chem. Soc. 2019, 141, 10883–10904.

Enantioselective Total Synthesis of (−)-Arcutinine

Wei Nie, Jing Gong, Zhihao Chen, Jiazhen Liu, Di Tian, Hao Song, Xiao-Yu Liu, Yong Qin J. Am. Chem. Soc. 2019, 141, 9712-9718.

Total Synthesis of (±) Maoecrystal V

J. Gong, G. Lin, W. Sun, C.-C. Li, Z. Yang, J. Am. Chem. Soc. 2010, 132, 16745-16745.

Total Syntheses of Bisdehydroneostemoninine and Bisdehydrostemoninine by Catalytic Carbonylative Spirolactonization

Ma, K.; Yin, X.; Prof. Dai, M. Angew. Chem. Int. Ed. 2018, 57, 15209-15212.

13-Step Total Synthesis of Atropurpuran

Xie, S.; Chen, G.; Yan, H.; Hou, J.; He, Y.; Zhao, T.; Xu, J. J. Am. Chem. Soc. 2019, 141, 3435-3439.

Divergent Total Synthesis of Indoxamycins A, C, and F

He, C.; Zhu, C.; Dai, Z.; Tseng, C. C.; Ding, H. Angew. Chem. Int. Ed. 2013, 52, 13256-13260.

Synthesis of Conidiogenol

Hu, P.; Chi, H.; DeBacker, K. C.; Gong, X.; Keim, J. H.; Hsu, I. T.; Snyder, S. A. Nature 2019, 569, 703-707.

Total Synthesis of (+)-Granatumine A and Related Bislactone Limonoid Alkaloids via a Pyran to Pyridine Interconversion

Schuppe, A.; Zhao, Y.; Liu, Y.; Newhouse, T. J. Am. Chem. Soc. 2019, 141, 9191-9196.

Total Synthesis of (+)-Arborisidine

Zhou, Z.; Gao, A. X.; Snyder, S. A. J. Am. Chem. Soc. 2019, 141, 7715-7720.

Total Synthesis of the Glycosylated Macrolide Antibiotic Fidaxomicin

Kaufmann, E.; Hattori, H.; Miyatake-Ondozabal, H.; Gademann, K.; Org. Lett. 2015, 17, 3514–3517;

Miyatake-Ondozabal, H.; Kaufmann, E.; Gademann, K.; Angew. Chem. Int. Ed. 2015, 54, 1933–1936.

Total Synthesis of (±) Bukittinggine

Stafford, J. A.; Heathcock, C. H.; Clark, D. L. J. Org. Chem. 1992, 57, 2575-2585.

Asymmetric Total Synthesis of Cerorubenic Acid-III

Liu, X.; Liu, J.; Wu, J.; Huang, G.; Liang, R.; Chung, L. W.; Li, C.-C. J. Am. Chem. Soc. 019, 141, 2872–2877.

The Enantioselective Total Synthesis of Exochomine

Gao, A. X.; Hamada, T.; Snyder, S. A. Angew. Chem. Int. Ed. 2016, 55, 10301-10306.

Scalable Total Synthesis of (-)-Vinigrol

Yu, X.; Xiao, L.; Wang, Z.; Luo, T. J. Am. Chem. Soc. 2019, 141, 3440–3443.

Synthesis of Ambiguine P

Johnson, R. E.; Ree, H.; Hartmann, M.; Lang, L.; Sawano, S.; Sarpong, R. J. Am. Chem. Soc. 2019, 141, 2233–2237.

Total Synthesis of Epicolactone

Kravina, A. G.; Carreira, E. M. Angew. Chem. Int. Ed. 2018, 57, 13159-13162.

Asymmetric Synthesis of Batrachotoxin: Enantiomeric Toxins show Functional Divergence against NaV

Logan, M. M.; Toma, T.; Thomas-Tran, R.; Du Bois, J.; Science 2016, 354, 865–869.

Total Synthesis of (-)-Isoschizogamine

Y. Miura, N. Hayashi, S. Yokoshima, and T. Fukuyama,  J. Am. Chem. Soc. 2012, 134, 11995-11997.

A Scalable Total Synthesis of the Antitumor Agents Et‐743 and Lurbinectedin

He, W.; Zhang, Z.; Ma, D. J. Am. Chem. Soc. 2019, 58, 3972-3975.

Total Synthesis of Aplysiasecosterol A

Lu, Z.; Zhang, X.; Guo, Z.; Chen, Y.; Mu, T.; Li, A. J. Am. Chem. Soc. 2018, 140, 9211-9218.

Total Synthesis of Astellatol

Zhao, N.; Yin, S.; Xie, S.; Yan, H.; Ren, P.; Chen, G.; Chen, F.; Xu, J. Angew. Chem. Int. Ed. 2018, 57, 3386–3390.

Total Syntheses of Various Amphilectane and Serrulatane Diterpenoids

Yu, X.; Su, F.; Liu, C.; Yuan, H.; Zhao, S.; Zhou, Z.; Quan, T.; Luo, T. J. Am. Chem. Soc. 2016, 138, 6261-6270.

Total Synthesis of (−)-Nahuoic Acid Ci (Bii)

Liu, Q.; Deng, Y.; Smith, A. B., III J. Am. Chem. Soc. 2017, 139, 13668–13671

Total Syntheses of Highly Oxidized ent-Kaurenoid Pharicin A, Pharicinin B, 7-O-Acetylpseurata C, and Pseurata C: A [5+2] Cascade Approach

He, C.; Hu, J.; Wu, Y.; Ding, H. J. Am. Chem. Soc. 2017, 139, 6098–6101.

Formal Total Synthesis of (+)-Pleuromutilin

Farney, E. P.; Feng, S. S.; Schäfers, F.; Reisman, S. E. J. Am. Chem. Soc. 2018, 140, 1267-1270.

Total Synthesis of Isodihydrokoumine, (19Z)‑Taberpsychine, and (4R)‑Isodihydroukoumine N4‑Oxide

Kerkovius, J. K.; Kerr, M. A. J. Am. Chem. Soc. 2018, 140, 8415-8419. 

Synthesis of (±)‐Merrilactone A by a Desymmetrization Strategy

Liu, W.; Wang, B. Chem. Eur. J. 2018, 24, 16511-16515.

A Benzyne-Insertion Approach to Hetisine-Type Diterpenoid Alkaloids: Synthesis of Cossonidine (Davisine).

Kou, K., G., M.; Pflueger, J., Kiho, T., Morrill, L., C.; Fisher, E., L.; Clagg, K.; Lebold, T., P.; Kisunzu, J., K.; Sarpong, R. J. Am. Chem. Soc. 2018, 140, 8105-8109.

Catalytic Asymmetric Total Synthesis of (−)-Actinophyllic Acid

Cai, L.; Zhang, K.; Kwon, O. J. Am. Chem. Soc. 2016, 138, 3298-3301.

Intramolecular Photocycloaddtion-Cyclobutane Fragmentation: Total Synthesis of (±)-Silphinene

Crimmins, M. T.; Mascarella, S. W. J. Am. Chem. Soc. 1986, 108, 3435-3438.

Total Synthesis of (-)-Histrionicotoxin and (-)-Histronicotoxine 235A

Stork, G.; Zhao, K. J. Am. Chem. Soc. 1990112, 5875-5876.

Total Synthesis of (±)-Nakafuran-8

Uyehara, T., Sugimoto, M., Suzuki, I., Yamamoto, Y., J. Chem. Soc. Chem. Commun. 1989, 1841-1842.

Total Synthesis of (−)-Chromodorolide B By a Computationally-Guided Radical Addition/Cyclization/Fragmentation Cascade

Tao, D. J.; Slutskyy, Y.; Muuronen, M.; Le, A.; Kohler, P.; Overman, L. E. J. Am. Chem. Soc. 2018, 140, 3091-3102.

Bioinspired Total Synthesis of Sespenine

Sun, Y.; Chen, P.; Zhang, D.; Baunach, M.; Hertweck, C.; Li, A. Angew. Chem. Int. Ed.2014, 53, 9012-9016.

Enantioselective Total Synthesis of (+) and (–)-Nigellamine A2

Bian, J.; van Wingerden, M.; Ready, J., M. J. Am. Chem. Soc. 2006, 128, 7428–7429.