THE TRAUNER RESEARCH GROUP
"Metal-Dependent Photodissociation of Hydrazone Photoswitches from Rare-Earth Complexes" Melegari, M.; Wilharm, R. K.; Silva, R. N.; Artizzu, F.; Serpe, A; Trauner, D.; Tegoni, M.; Schelter, E. J.; Marchiò, L. J. Am. Chem. Soc., Article ASAP
"Concise Synthesis of Stephadiamine via Vinylogous Wenker Cyclization" Serna Moyeda, A. V.; Trauner, D. ChemRxiv, 2026 https://chemrxiv.org/doi/full/10.26434/chemrxiv.15001557/v1
Ge, X.; Willems, S.; Melfi, F.; Mukhopadhyay, T.; Morstein, J.; Artzy, J.; Knümann, L.; Sbriccoli, G.; Pabel, J.; Marschner, J. A.; Trauner, D.; Merk, D. Angewandte Chemie International Edition, 2026
"Localized NF-κB Inhibition Reduces Lipid Nanoparticle-Associated Inflammation" Espy, C.L.; Wu, J.; Omo-Lamai, S.; Wang, L.; Dong, F.; Milosavljevic, A.; O'Neill, S.; Brysgel, T.; Wang, Y.; Zaleski, M.; Wolfe, E.; Maheshwari, R.; Patel, M.; Trauner, D.; Nong, J.; Wang, Z.; Brenner, J.S. Adv. Sci. (Weinh), 2026
"Photocontrolled trimethoprim PROTACs targeting the eDHFR protein tag" Sharma, N.; Sarkar, S.; Ko, T.; Edwards, K. J.; Pham, J. M.; Nguyen, T.; Gong, A. Z.; Flores, J.; Trauner, D.; Sellmyer, M. Nat. Commun. 2025
"Development of Photoswitchable Cholesterol Derivatives through Side Chain Replacement" Zott, M. D.; Behnsen, A.; Depta, L.; Lester, B. C.; Laraia, L.; Trauner, D. H. Journal of the American Chemical Society 2025, 147 (47), 43798-43804
"A prodrug targeting CIM6P/IGF2R enhances memory in healthy mice and reverses deficits in an Angelman syndrome mouse model" Aria, F.; Arp, C. J.; Prikas, E.; Goodwin-Groen, S.; Pandey, K.; Munari, L.; Patel, S.; Trauner, D.; Alberini, C. M. Translational Psychiatry 2025, 15 (1), 438
"Photolipid Isomerization in Multicomponent Lipid Membranes: Effects of Temperature and Charge" D. Kammerer, D. Trauner, T. Lohmueller, Langmuir 2025 41 (34), 23025-23035
Synthesis of Collinoketones via Biomimetic [6+4] Cycloaddition” Reiter, H.;Mukhopadhyay, T.; Zhao, F.; Zhou, Q.; Liu, F.; Houk, K. N.; Trauner, D. ChemRxiv 2025, https://chemrxiv.org/engage/chemrxiv/article-details/68bb0dcd728bf9025e9dac40(resubmitted to J. Am. Chem. Soc).
“Synthetic Studies on Lolium Alkaloids” Zuschlag, D. W.; Cakmak, M.; Kuttruff, C.; Mayert, P.; Trauner, D. Synthesis 2025
"Optical Control of Membrane Fluidity Modulates Protein Secretion" Jiménez-Rojo, N.; Feng, S.; Morstein, J.; Pritzl, S. D.; Harayama, T.; Asaro, A.; Vepřek, N. A.; Arp, C. J. Reynders, M.; Novak, A. J. E.; Kanshin, E.; Ueberheide, B.; Lohmüller, T.; Riezman, H.; Trauner, D. ACS Central Science Article ASAP
"Limiting Endosomal Damage Sensing Reduces Inflammation Triggered by Lipid Nanoparticle Endosomal Escape" Omo-Lamai, S.; Wang, Y.; Patel, M. N.; Milosavljevic, A.; Zuschlag, D.; Poddar, S.; Wu, J.; Wang, L.; Dong, F.; Espy, C.; Majumder, A.; Essien, E.-O.; Shen, M.; Channer, B.; Papp, T. E.; Tobin, M.; Maheshwari, R.; Jeong, S.; Patel, S.; Shah, A.; Murali, S.; Chase, L. S.; Zamora, M. E.; Arral, M. L.; Marcos-Contreras, O. A.; Myerson, J. W.; Hunter, C. A.; Discher, D.; Gaskill, P. J.; Tsourkas, A.; Muzykantov, V. R.; Brodsky, I.; Shin, S.; Whitehead, K. A.; Parhiz, H.; Katzen, J.; Miner, J. J.; Trauner, D.; Brenner, J. S. Nat. Nanotechnol. 2025, 1–13.
"Breaking a Lewis Acidity Trend for Rare Earths by Excited State Quenching" Wilharm, R. K.; Gau, M. R.; Trauner, D.; Schelter, E. J. J. Am. Chem. Soc., Article ASAP
"Reversible Antagonism of Dopamine D1 Receptor using a Photoswitchable Remotely Tethered Ligand." Hetzler, B. E.; Donthamsetti, P.; Wolesensky, R. M.; Stanley, C.; Isacoff, E. Y.; Trauner, D. bioRxiv 2025
"Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation." Soto-Moreno, E. J.; Ali, N. N.; Küller, F.; Nasufovic, V.; Frolikova, M.; Tepla, O.; Masata, J.; Trauner, D.; Patterson, A. A.; Arndt, H.-D.; Komrskova, K.; Zernicka-Goetz, M.; Glover, D. M.; Balboula. A.Z. bioRxiv 2025
"The Chemistry and Biology of the Tetrodotoxin Natural Product Family" Nißl, B.; Mülbaier, M.; Grisoni, F.; Trauner, D.; Bermúdez, M.; Dialer, C.; Konrad, D. Angew. Chem. Int. Ed.2025, e202502404.
"Time-Lapse Super-Resolution Imaging and Optical Manipulation of Growth Cones in Elongating Axons and Migrating Neurons" Sawada, M.; Nakajima, C.; Umeda, E.; Takagi, Y.; Nakashima, N.; Vepřek, N. A.; Küllmer, F.; Nasufović, V.; Arndt, H.; Trauner, D.; Igarashi, M.; Sawamoto, K. Bio-protocol, 2025, 15(6): e5251.
"Photoswitchable phospholipids for the optical control of membrane processes, protein function, and drug delivery" Pritzl, S. D.; Morstein, J.; Pritzl, N. A.; Lipfert, J.; Lohmüller T.; Trauner, D. Commun Mater, 2025, 65
"Stereoselective Synthesis of Benzoylated Gulmirecin A and Disciformycin B" Rühmann, P-K.; Ji, K.; Trauner D. Org. Lett. 2025, 27, 1584–1589.
"Reaction Development: a Student's Checklist" Tyler J. L.; Trauner D.; Glorius F. Chem. Soc. Rev., 2025, Advance Article.
"Dopamine D1 receptor activation in the striatum is sufficient to drive reinforcement of anteceding cortical patterns" Vendrell-Llopis, N.; Read, J.; Boggiano, S.; Hetzler, B.; Peitsinis, Z.; Stanley, C.; Visel, M.; Trauner, D.; Donthamsetti, P.; Carmena, J.; Lammel, S.; Isacoff, E. Y. Neuron, 2025, 113, 785-794.
"An opioid efficacy switch for reversible optical control of peripheral analgesia" Posa, L.; Romano, G.; Ji, X.; Khan, S.; Paz, B. M.; Han, G. W.; Nazarova, A. L.; Zaidi, S. A.; Ranjbar, M.; Pleil, K.; Katritch, V.; Gati, C.; Trauner, D.; Levitz J. Biorxiv, 2025
"Biomimetic Synthesis of Azorellolide via Cyclopropylcarbinyl Cation Chemistry" Artzy, J. Y.; Tantillo, D. J.; Trauner, D. J. Am. Chem. Soc. 2025, 147, 78-83.
"Concise Synthesis of (–)-Veratramine and (–)-20-epi-Veratramine via Aromative Diels-Alder Reaction" Zott M.; Zuschlag D.; Trauner D. J. Am. Chem. Soc. 2025, 147, 3010-3016.
"Photoswitchable Diazocine Derivative for Adenosine A3 Receptor Activation in Psoriasis" López-Cano, M.; Scortichini, M.; Tosh, K. D.; Salmaso, V.; Ko, T.; Salort, G.; Filgaira, I.; Soler, C.; Trauner, D.; Hernando, J.; Jacobson, A. K.; Ciruela F. J. Am. Chem. Soc. 2025, 147, 874-879.
"Optical Control of Cardiac Electrophysiology by the Photochromic Ligand AzoBupivacaine 2" Fehrentz, T.; Amin, E.; Görldt, N.; Strasdeit, T.; Moussavi-Torshizi, S. E.; Leippe, P.;Trauner, D.; Meyer, C.; Frey, N.; Sasse, P.; Klöcker, N. British J. Pharm., 2025, 82, 1125-1142.
"Optical control of sphingolipid biosynthesis using photoswitchable sphingosines" Kol, M.; Novak, A.; Morstein, J.; Schröer, C.; Sokoya, T.; Mensing, S.; Korneev, S. M.; Trauner, D.; Holthuis J. Journal of Lipid Research, 2024, 100724
"Neuroprotective effect of neuron-specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis" Amatruda, M.; Marechal, D.; Gacias, M.; Wentling, M.; Turpin-Nolan, S.; Morstein, J.; Moniruzzaman, M.; Brüning, J. C.; Haughey, N. J.; Trauner, D. H.; Casaccia, P. Glia, 2024, 1-20.
"Cell-Specific Optical Control of AMPA Glutamate Receptors with a Photoswitchable Tethered Antagonist" Trauner, D.; Leipppe, P.; Donthamsetti, P.; Ko, T.; Stanley, C.; Isacoff, E. Angew. Chem. Int. Ed. 2024, e202411181.
"Light-Activatable, Cell-Type Specific Labeling of the Nascent Proteome" Evans, H. T.; Ko, T.; Oliveira, M. M.; Yu, A.; Kalavai, S. V.; Golhan, E. N.; Polavarapu, A.; Balamoti, E.; Wu, V.; Klann, E.; Trauner, D. ACS Chemical Neuroscience 2024, 15, 3473-348.
"Optical Control of TRPM8 Channels with Photoswitchable Menthol" Becker, J.; Ellerkmann, C. S.; Schmelzer, H.; Hermann, C.; Lützel, K.; Gudermann, T.; Konrad, D. B.; Trauner, D.; Storch, U.; Mederos Y. S. M. Angew. Chem. Int. Ed. 2024, e202416549.
"Pixelated High-Q Metasurfaces for in Situ Biospectroscopy and Artificial Intelligence-Enabled Classification of Lipid Membrane Photoswitching Dynamics" Barkey, M.; Büchner, R.; Wester, A.; Pritzl, S. D.; Makarenko, M.; Wang, Q.; Weber, T.; Trauner, D.; Maier, S. A.; Fratalocchi, A.; Lohmüller, T.; Tittl. ACS Nano 2024 18 (18), 11644-11654
"Synthetic Efforts toward Lannotinidine G Based on an Aziridinium-Mediated Ring Contraction and Dienyne Metathesis" Peitsinis Z.; Trauner. D. H. Org. Lett. 2024, 26, 3184–3188.
"Optical Control of G-Actin with a Photoswitchable Latrunculin" Vepřek, N. A.; Cooper, M. H.; Laprell, L.; Yang, E. J.-N.; Folkerts, S.; Bao, R.; Boczkowska, M.; Palmer, N. J.; Dominguez, R.;Oertner, T. G.; Pon, L. A.; Zuchero, J. B.; Trauner, D. H. J. Am. Chem. Soc. 2024,146, 8895–8903.
"Identification of the Growth Cone as a Probe and Driver of Neuronal Migration in the Injured Brain“ Nakajima, C.; Sawada, M.; Umeda, E.; Takagi, Y.; Nakashima, N.; Kuboyama, K.; Kaneko, N.; Yamamoto, S.; Nakamura, H.; Shimada, N.; Nakamura, K.; Matsuno, K.; Uesugi, S.; Vepřek, N. A.; Küllmer, F.; Nasuvović, V.; Uchiyama, H.; Nakada, M.; Otsuka, Y.; Ito, Y.; Herantz-Pérez, V.; Garcia-Verdugo, J.-M.; Ohno, M.; Arndt, H.-D.; Trauner, D.; Tabata, Y.; Igarashi, M; Sawamoto, K. Nature Commun., 2024, 15, 1-19.
"Optical Control of Proteasomal Protein Degradation with a Photoswitchable Lipopeptide" Morstein, J.; Amatuni, A.; Shuster, A.; Kuttenlochner, W.; Ko, T.; Abegg, D.; Groll, M.; Adibekian, A.; Renata, H.; Trauner, D. H. Angew. Chem. Int. Ed. 2024, 63, e2023147.
"Photoswitchable Inhibitors of the Sarco(endo)plasmic Calcium Pump" Hjorth-Jensen, S. J.; Konrad, D. B.; Quistgaard, E. M. H.; Hansen, L. C.; Novak, A.; Chu, H.; Jurášek, M.; Zimmermann, T.; Andersen, J. L.; Baran, P. S.; Nissen, P.*; Trauner, D.* ChemRxiv 2023
"Photoactivated Protein Degrader for Optical Control of Synaptic Function" Ko, T.; Jou, C.; Grau-Perales, A. B.; Reynders, M.; Fenton, A. A.; Trauner, D. ACS Chem. Neurosci. 2023, 14, 3704–3713.
"Optical Control of Dopamine D2-like Receptors with Cell-Specific Fast-Relaxing Photoswitches" Hetzler, B. E.; Donthamsetti, P.; Peitsinis, Z.; Stanley, C.; Trauner, D.; Isacoff, E. Y. J. Am. Chem. Soc. 2023, 145, 18778–18788.
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"Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation" Arp, C. J.; Reynders, M.; Sreekanth, V.; Kokkonda, P.; Pagano, M.; Choudhary, A.; Trauner, D. bioRxiv 2023.
"To Isomerize or not to Isomerize? E /Z Isomers of Cyclic Azobenzene Derivatives and their Reactivity upon One-Electron Reduction" Glotz, G.; Knaipp, K.; Maier, M. S.; Hüll, K.; Novak, A.; Kelterer, A.-M.; Griebenow, T.; Herges, R.; Trauner, D.; Gescheidt, G. Chem. Eur. J. 2023, e202300146
"Development of Light Activated LXR Agonists" Mukhopadhyay, T. K.; Willems, S.; Arp, C. J.; Morstein, J.; Haake, C. T.; Merk, D.; Trauner, D. ChemMedChem 2023, e202200647
"Structural diversity of photoswitchable sphingolipids for optodynamic control of lipid microdomains" Hartrampf, N.; Leitao, S. M.; Winter, N.; Toombs-Ruane, H.; Frank, J. A.; Schwille, P.; Trauner, D.; Franquelim, H. G. Biophys. J. 2023, 22, 1–17.
"Fluorescent Azobenzene-Confined Coiled-Coil Mesofibers" Punia, K.; Britton, D.; Hüll, K.; Yin, L.; Wang, Y.; Renfrew, P. D.; Gilchrist, M. L.; Bonneau, R.; Trauner, D.; Montclare, J. K. Soft Matter, 2023, 19, 497-501.
"Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes" Simon, J.; Schwalm, M.; Morstein, J.; Trauner, D.; Jasanoff, A. Nat. Biomed. Eng. 2023, 7, 313–322.
"Concise Synthesis of Glycerophospholipids" Mukhopadhyay, T. K.; Trauner, D. J. Org. Chem. 2023, 88, 11253–11257.
"Optical Control of Translation with a Puromycin Photoswitch" Ko, T.; Oliveira, M. M.; Alapin, J. M.; Morstein, J.; Klann, E.; Trauner, D. J. Am. Chem. Soc. 2022, 144, 21494–21501.
"Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation" Morstein, J.; Bader, T.; Cardillo, A. L.; Schackmann, J.; Ashok, S.; Hougland, J. L.; Hrycyna, C. A.; Trauner, D. H.; Distefano, M. D. ACS Chem. Biol. 2022, 17, 2945–2953.
"Medium-Chain Lipid Conjugation Facilitates Cell-Permeability and Bioactivity" Morstein, J.; Capecchi, A.; Hinnah, K.; Park, B.; Petit-Jacques, J.; Van Lehn, R. C.; Reymond, J.-L.; Trauner, D. J. Am. Chem. Soc. 2022, 144, 18532–18544.
"Postsynthetic Photocontrol of Giant Liposomes via Fusion-Based Photolipid Doping" Pritzl, S. D.; Morstein, J.; Kahler, S.; Konrad, D. B.; Trauner, D.; Lohmüller, T. Langmuir 2022, 38, 11941–11949.
"Optical Control of Neuronal Activities with Photoswitchable Nanovesicles" Xiong, H.; Alberto, K. A.; Youn, J.; Taura, J.; Morstein, J.; Li, X.; Wang, Y.; Trauner, D.; Slesinger, P. A.; Nielsen, S. O.; Qin, Z. Nano Res. 2023, 16, 1033–1041.
"Next Generation Opto-Jasplakinolides Enable Local Remodeling of Actin Networks" Küllmer, F.; Vepřek, N. A.; Borowiak, M.; Nasufović, V.; Barutzki, S.; Thorn-Seshold, O.; Arndt, H-D.; Trauner, D. Angew. Chem. Int. Ed. 2022, e202210220.
"Assembling the carbon skeleton of A-74528" Maier, M. S.; Shemet, A.; Trauner, D. Chem. Sci., 2022, 13, 8395–8400
"Photoactivation of a Mechanosensitive Channel" Crea, F.; Vorka, A.; Redlich, A.; Cruz, R.; Shi, C.; Trauner, D.; Lange, A.; Schlesinger, R.; Heberle, J. Front. Mol. Biosci. 2022, 9, 905306.
"Complex Natural Products Derived from Pyrogallols" Novak, A. J. E.; Trauner, D. In Progress in the Chemistry of Organic Natural Products 118; Kinghorn, A. D., Falk, H., Gibbons, S., Asakawa, Y., Liu, J.-K., Dirsch, V. M.; Springer International Publishing: Cham, 2022, 1-46.
"Photopharmacological Control of Cell Signaling with Photoswitchable Lipids” Mukhopadhyay, T. K.; Morstein, J.; Trauner D. Curr. Opin. Pharmacol. 2022, 63, 102202
"Natural product anticipation through synthesis" Hetzler, B. E.; Trauner, D.; Lawrence, A. L. Nat. Rev. Chem. 2022, 6, 170–181.
"A Concise Synthesis of Tetrodotoxin" Konrad, D. B.; Rühmann, K-P.; Ando, H.; Hetzler, B. E.; Matsuura, B. S.; Trauner, D. Science. 2022, 377, 411–415.
"Optical Membrane Control with Red Light Enabled by Red-Shifted Photolipids" Pritzl, S. D.; Konrad, D. B.; Ober, M. F.; Richter, A. F.; Frank, J. A.; Nickel, B.; Trauner, D.; Lohmüller, T. Langmuir 2022, 38, 385–393.
"Optical Control of Mitosis with a Photoswitchable Eg5 Inhibitor" Impastato, A. C.; Shemet, A.; Vepřek, N. A.; Saper, G.; Rao, L.; Hess, H.; Gennerich, A.; Trauner, D. Angew. Chem. Int. Ed. 2022, 61, e2021158.
"Photoswitchable Serotonins for Optical Control of the 5-HT2A Receptor" Morstein, J.; Romano, G.; Hetzler, B.; Plante, A.; Haake, C.; Levitz, J.; Trauner, D. Angew. Chem. Int. Ed. 2022, e202117094.
"Optical Control of Glycerolipids and Sphingolipids" Trauner, D.; Morstein, J. Chimia 2021, 75, 1022–1025.
"Cholesterol and sphingomyelin are critical for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages" Bryan, A. M.; You, J. K.; Li, G.; Kim, J.; Singh, A.; Morstein, J.; Trauner, D.; Pereira de Sá, N.; Normile, T. G.; Farnoud, A. M.; London, E.; Del Poeta, M. J. Biol. Chem. 2021, 297, 101411.
"PHOTACs Enable Optical Control of Protein Degradation" Reynders, M.; Trauner, D. (Book Chapter) In Targeted Protein Degradation: Methods and Protocols; Cacace, A. M.,Hickey, C. M., Békés, M., Eds.; Springer US: New York, NY, 2021, 315-329.
"Optical Control of Adenosine-Mediated Pain Modulation" Hüll, K.; Fernández-Dueñas, V.; Schönberger, M.; López-Cano, M.; Trauner, D.; Ciruela, F. Bioconjugate Chem. 2021, 32, 1979–1983.
"De novo Design of SARS-CoV-2 Main Protease Inhibitors" Fischer, C.; Vepřek, N. A.; Peitsinis, Z.; Rühmann, K-P.; Yang, C.; Spradlin, J. N.; Dovala, D.; Nomura, D. K.; Zhang, Y.; Trauner, D. Synlett, 2021, 32, A–F.
"Cell specific photoswitchable agonist for reversible control of endogenous dopamine receptors" Donthamsetti, P.; Winter, N.; Hoagland, A.; Stanley, C.; Visel, M.; Lammel, S.; Trauner, D.; Isacoff, E. Nat. Commun. 2021, 12, 4775.
"Optical Control of Phosphatidic Acid Signaling" Tei, R.; Morstein, J.; Shemet, A.; Trauner, D.; Baskin, J. M. ACS Cent. Sci. 2021, 7, 1205–1215.
Open Access
"A Photohormone for Light-Dependent Control of PPARα in Live Cells" Willems, S.; Morstein, J.; Hinnah, K.; Trauner, D.; Merk, D. J. Med. Chem. 2021, 64, 10393–10402.
"How Photoswitchable Lipids Affect the Order and Dynamics of Lipid Bilayers and Embedded Proteins" Doroudgar, M.; Morstein, J.; Becker-Baldus, J.; Trauner, D.; Glaubitz. C. J. Am. Chem. Soc. 2021, 143, 9515–9528.
"Perfect and Defective 13C-Furan-Derived Nanothreads from Modest-Pressure Synthesis Analyzed by 13C NMR" Matsuura, B. S.; Huss, S.; Zheng, Z.; Yuan, S.; Wang, T.; Chen, B.; Badding, J. V.; Trauner, D.; Elacqua, E.; van Duin, A. C. T.; Crespi, V. H.; Schmidt-Rohr, K. J. Am. Chem. Soc. 2021, 143, 9529–9542.
"Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor" Donthamsetti, P.; Konrad, D. B.; Hetzler, B.; Fu, Z.; Trauner, D.; Isacoff, E. Y. J. Am. Chem. Soc. 2021, 143, 8951–8956.
Open Access
"Optical control of targeted protein degradation" Reynders, M.; Trauner, D. Cell Chem. Bio. 2021, 28, 969–986.
"Controlling the Covalent Reactivity of a Kinase Inhibitor with Light" Reynders, M.; Chaikuad, A.; Berger, B.-T.; Bauer, K.; Koch, P.; Laufer, S.; Knapp, S.; Trauner, D. Angew. Chem. Int. Ed. 2021, 60, 20178 –20183
"Computational Exploration of the Mechanism of Critical Steps in the Biomimetic Synthesis of Preuisolactone A, and Discovery of New Ambimodal (5 + 2)/(4 + 2) Cycloadditions" Zhang, H.; Novak, A. J. E.; Jamieson, C. S.; Xue, X; Chen, S.; Trauner, D.; Houk, K. N. J. Am. Chem. Soc. 2021, 143, 6601–6608.
"Optimized Photoactivatable Lipid Nanoparticles Enable Red Light Triggered Drug Release" Chander, N.; Morstein, J.; Bolten, J. S.; Shemet, A.; Cullis, P. R.; Trauner, D.; Witzigmann, D. Small 2021, 17, 2008198
"Short Photoswitchable Ceramides Enable Optical Control of Apoptosis" Morstein, J.; Kol, M.; Novak, A. J. E.; Feng, S.; Khayyo, S.; Hinnah,K.; Li-Purcell, N.; Pan, G.; Williams, B. M.; Riezman, H.; Atilla-Gokcumen, G. E.; Holthuis, J. C. M.; Trauner, D. ACS Chem. Biol. 2021, 16, 452–456.
"Photolipid Bilayer Permeability is Controlled by Transient Pore Formation" Pritzl, S. D.; Urban, P.; Prasselsperger, A.; Konrad, D. B.; Frank, J. A.; Trauner, D.; Lohmüller, T. Langmuir 2020, 36, 13509–13515.
"Reflections on Racemic Natural Products" Novak, A. J. E.; Trauner, D. Trends Chem. 2020, 2, 1052–1065.
"Metabolic Tuning of Inhibition Regulates Hippocampal Neurogenesis in the Adult Brain" Wang, X.; Liu, H.; Morstein, J.; Novak, A. J. E.; Trauner, D.; Xiong, Q.; Yu, Y.; Ge, S. Proc. Natl. Acad. Sci. U.S.A. 2020, 117, 25818–25829.
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"Photoswitchable Paclitaxel-Based Microtubule Stabilisers Allow Optical Control Over the Microtubule Cytoskeleton" Müller-Deku, A.; Loy, K.; Kraus, Y.; Heise, C.; Bingham, R.; Ahlfeld, J.; Trauner, D.; Thorn-Seshold, O. Nat. Commun. 2020, 11, 4640.
"Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ)" Hinnah, K.; Willems, S.; Morstein, J.; Heering, J.; Hartrampf, F. W. W.; Broichhagen, J.; Leippe, P.; Merk, D.; Trauner, D. J. Med. Chem. 2020, 63, 10908–10920.
"Photoswitchable Lipids" Morstein, J.; Impastato, A. C.; Trauner, D. Chem. Bio. Chem. 2020, 22, 73–83.
"Light-induced lipid mixing implies a causal role of lipid splay in membrane fusion" Scheidt, H. A.; Kolocaj, K.; Konrad, D. B.; Frank, J. A.; Trauner, D.; Langosch, D.; Huster, D. BBA - Biomembranes 2020, 1862, 1834382.
"A Conversation with Gerhard Bringmann" Trauner, D.; Roßmann, K. ACS Cent. Sci. 2020, 6, 1248–1252.
"Potential energy function for a photo‐switchable lipid molecule" Klaja, O.; Frank, J. A.; Trauner, D.; Bondar, A.-N. J. Comput. Chem. 2020, 41, 2336–2351.
"Optical Control of Lysophosphatidic Acid Signaling" Morstein, J.; Dacheux, M. A.; Norman, D. D.; Shemet, A.; Donthamsetti, P. C.; Citir, M.; Frank, J. A.; Schultz, C.; Isacoff, E. Y.; Parrill, A. L.; Tigyi, G. J.; Trauner, D. J. Am. Chem. Soc. 2020, 24, 10612–10616.
"Optical Manipulation of F-Actin with Photoswitchable Small Molecules" Borowiak, M.; Küllmer, F.; Gegenfurtner, F.; Peil, S.; Nasufovic, V.; Zahler, S.; Thorn-Seshold, O.; Trauner, D.; Arndt, H.-D. J. Am. Chem. Soc. 2020, 142, 9240–9249.
"Microtubules control cellular shape and coherence in amoeboid migrating cells" Kopf, A.; Renkawitz, J.; Hauschild, R.; Girkontaite, I.; Tedford, K.; Merrin, J.; Thorn-Seshold, O.; Trauner, D.; Häcker, H.; Fischer, K. D.; Kiermaier, E.; Sixt, M. J. Cell Biol. 2020, 219, e201907154.
"Photopharmacological control of lipid function" Morstein, J.; Trauner, D. Methods Enzymol. 2020, 638, 219–232.
"A Photoswitchable Inhibitor of the Human Serotonin Transporter" Cheng, B.; Morstein, J.; Ladefoged, K. L.; Maesen, J. B.; Schiøtt, B.; Sinning, S.; Trauner, D. ACS Chem. Neurosci. 2020, 11, 1231–1237.
"Computational Design and Synthesis of a Deeply Red-Shifted and Bistable Azobenzene" Konrad, D. B.; Savasci, G.; Allmendinger, L.; Trauner, D.; Ochsenfeld, C.; Ali, A. M. J. Am. Chem. Soc. 2020, 142, 6538–6547.
Open Access
"PHOTACs Enable Optical Control of Protein Degradation" Reynders, M.; Matsuura, B.; Bérouti, M.; Simoneschi, D.; Marzio, A.; Pagano, M.; Trauner, D. Sci. Adv. 2020, 6, eaay5064.
Highlighted in Synfacts
"A Lipid Photoswitch Controls Fluidity in Supported Bilayer Membranes" Urban, P.; Pritzl, S. D.; Ober, M. F.; Dirscherl, C. F.; Pernpeintner, C.; Konrad, D. B.; Frank, J. A.; Trauner, D.; Nickel, B.; Lohmüller, T. Langmuir 2020, 36, 2629–2634.
"Optical Control of the Nuclear Bile Acid Receptor FXR with a Photohormone" Morstein, J.; Trads, J. B.; Hinnah, K.; Willems, S.; Barber, D. M.; Trauner, M.; Merk, D.; Trauner, D. Chem. Sci. 2020, 11, 429–434.
"Transformation of Receptor Tyrosine Kinases into Glutamate Receptors and Photoreceptors" Leippe, P.; Broichhagen, J.; Cailliau, K.; Mougel, A.; Morel, M.; Dissous, C.; Vicogne, J.; Trauner, D. Angew. Chem. Int. Ed. 2020, 59, 6720–6723.
"Optical Control of Cytokine Production Using Photoswitchable Galactosylceramides" Trauner, D.; Hartrampf, N.; Seki, T.; Baumann, A.; Watson, P.; Hoffmann-Röder, A.; Tsuji, M.; Veprek, N.; Hetzler, B. Chem. Eur. J. 2020, 26, 4476–4479.
"Bioinspired Synthesis of (–)-PF-1018." Quintela-Varela, H.; Jamieson, C.; Shao, Q.; Houk, K.; Trauner, D. Angew. Chem. Int. Ed. 2020, 59, 5263–5267.
"Oxidative Approach Enables Efficient Access to Cyclic Azobenzenes" Maier, M. S.; Hüll, K.; Reynders, M.; Matsuura, B. S.; Leippe, P.; Ko, T.; Schäffer, L.; Trauner, D. J. Am. Chem. Soc. 2019, 141, 17295–17304.
"Synthesis of acremines A, B and F and studies on the bisacremines" Winter, N.; Trauner, D. Beilstein J. Org. Chem. 2019, 15, 2271–2276.
"Fixing a Photosensitizer Unlocks and Localizes Its Lethality" Trauner, D.; Morstein, J. ACS Cent. Sci. 2019, 5, 1636–1638.
Open Access
"Photopharmacologic Vision Restoration Reduces Pathological Rhythmic Field Potentials in Blind Mouse Retina" Hüll, K.; Benster, T.; Manookin, M. B.; Trauner, D.; Van Gelder, R. N.; Laprell, L. Sci. Rep. 2019, 9, 13561.
"A Biomimetic Synthesis Elucidates the Origin of Preuisolactone A" Novak, A. J. E.; Grigglestone, C.; Trauner, D. J. Am. Chem. Soc. 2019, 141, 15515–15518.
"Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor" Donthamsetti, P. C.; Broichhagen, J.; Vyklicky, V.; Stanley, C.; Fu, Z.; Visel, M.; Levitz, J. L.; Javitch, J. A.; Trauner, D.; Isacoff, E. Y. J. Am. Chem. Soc. 2019, 141, 11522–11530.
"Two-Dimensional Electronic Spectroscopy Reveals the Spectral Dynamics of Förster Resonance Energy Transfer" Petkov, B. K.; Gellen, T. A.; Farfan, C. A.; Carbery, W. P.; Hetzler, B. E.; Trauner, D.; Li, X.; Glover, W. J.; Ulness, D. J.; Turner, D. B. Chem 2019, 5, 1928–1929.
"New players in phototherapy: photopharmacology and bio-integrated optoelectronics" Morstein, J.; Trauner, D. Curr. Opin. Chem. Biol. 2019, 50, 145–151.
"Synthesis and biological evaluation of (±)-hippolachnin and analogs" Winter, N.; Rupcic, Z.; Stadler, M.; Trauner, D. J. Antibiot. 2019, 72, 375–383.
"Sign Inversion in Photopharmacology: Incorporation of Cyclic Azobenzenes in Photoswitchable Potassium Channel Blockers and Openers" Trads, J.; Hüll, K.; Matsuura, B.; Laprell, L.; Fehrentz, T.; Görldt, N.; Kozek, K. A.; Weaver, D.; Klöcker, N.; Barber, D.; Trauner, D. Angew. Chem. Int. Ed. 2019, 58, 15421–15428.
"Optical control of sphingosine-1-phosphate formation and function" Morstein, J.; Hill, R. Z.; Novak, A. J. E.; Feng, S.; Norman, D. D.; Donthamsetti, P. C.; Frank, J. A.; Harayama, T.; Williams, B. M.; Parrill, A. L.; Tigyi, G. J.; Riezman, H.; Isacoff, E. Y.; Bautista, D. M.; Trauner, D. Nat. Chem. Biol. 2019, 15, 623–631.
"Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course" Castro, K.; Ntranos, A.; Amatruda, M.; Petracca, M.; Kosa, P.; Chen, E. Y.; Morstein, J.; Trauner, D.; Watson, C. T.; Kiebish, M. A.; Bielekova, B.; Inglese, M.; Katz Sand, I.; Casaccia, P. EBioMedicine 2019, 43, 392–410.
"Mapping the Azolog Space Enables the Optical Control of New Biological Targets" Morstein, J.; Awale, M.; Reymond, J.-L.; Trauner, D. ACS Cent. Sci. 2019, 5, 607–618.
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"Optical Manipulation of Sphingolipid Biosynthesis Using Photoswitchable Ceramides" Kol, M.; Williams, B.; Toombs-Ruane, H.; Franquelim, H. G.; Korneev, S.; Schroeer, C.; Schwille, P.; Trauner, D.; Holthuis, J. C. M.; Frank, J. A. eLife 2019; 8:e43230.
"Concise Asymmetric Synthesis of Kweichowenol A" Konrad, D. B.; Kicin, B.; Trauner, D. Synlett 2019, 30, 383–386.
"A Biomimetic Approach Toward Enterocin and Deoxyenterocin" Rizzo, A.; Mayer, R.; Trauner, D. JOC 2019, 84, 3, 1162–1175.
"Light-Controlled Lipid Interaction and Membrane Organization in Photolipid Bilayer Vesicles" Urban, P.; Pritzl, S., D.; Konrad, D., B.; Frank, J., A., Pernpeintner, C.; Roeske, C., R.; Trauner, D.; Lohmüller T. Langmuir 2018, 34, 13368–13374.
"Optical tools for understanding the complexity of β-cell signalling and insulin release" Frank, J. A.; Broichhagen, J.; Yushchenko, D., A.; Trauner, D.; Schultz, C.; Hodson, D., J. Nat. Rev. Endocrinol. 2018, 14, 721–737.
"Biomimetic Synthesis of (+)‐Aspergillin PZ" Reyes, J., Winter, N., Spessert, L., Trauner, D., Angew. Chem. Int. Ed. 2018, 57, 15587–15591.
"Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors" Durand-de Cuttoli, R.; Mondo,loni, S.; Marti, F.; Lemoine, D.; Nguyen, C.; Naude, J.; D'Izarnt-Gargas, T.; Pons, S.; Maskos, U.; Trauner, D.; Kramer, R., H.; Faure, P.; Mourot, A. eLife, 2018, e37487.
"Optical Control of a Delayed Rectifier and a Two-Pore Potassium Channel with a Photoswitchable Bupivacaine" Leippe, P.; Winter, N.; Sumser, M., P. ACS Chem. Neurosci. 2018, 9, 2886–2891.
“A Versatile Bis-Allylboron Reagent for the Stereoselective Synthesis of Chiral Diols” Hetzler, B. E.; Volpin, G.; Vignoni, E.; Petrovic, A. P.; Proni, G; Chunhua, T, H.; Trauner, D.* Angew. Chem. Int. Ed. 2018, 57, 14276–14280.
"Optical Control of L-Type Ca2+ Channels Using a Diltiazem Photoswitch" Fehrentz,T.; Huber, F. M. E.; Vrielink, N.; Bruegmann, T.; Frank, J. A.; Fine, N. H. F.; Malan, D.; Danzl, J. G.; Tikhonov, D. B.; Sasse, P.; Hodson, D. J.; Zhorov. B. S.; Klöcker, N.*; Trauner, D.* Nature Chem. Biol. 2018, 14, 764–767.
"In Vivo Photopharmacology" Hüll, K.; Morstein, J.; Trauner, D. Chem. Rev. 2018, 118, 10710–10747.
"Total Synthesis of (±)-Exotine B". Cheng, B.; Volpin, G.; Morstein, J.; Trauner., D. Org. Lett. 2018, 20, 4358–4361.
Open Access, ACS Editors' Choice
Toward (−)-Enterocin: An Improved Cuprate Barbier Protocol To Overcome Strain and Sterical Hindrance" Rizzo. A.; Trauner, D. Org. Lett. 2018, 20, 1841–1844.
"Total Synthesis of the Norhasubanan Alkaloid Stephadiamine"Hartrampf, N.; Winter, N.; Pupo, G.; Stoltz, B.; Trauner, D.* J. Am. Chem. Soc. 2018, 140, 8675–-8680.
"Azomethine Ylide Cycloaddition Approach toward Dendrobine: Synthesis of 5-Deoxymubironine C" Williams, B. M.; Trauner D. J. Org. Chem. 2018, 83, 3061–3068.
"Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology" Podewin, T.; Ast, J.; Broichhagen, J.; Fine, N. H. F.; Nateska, J.; Leippe, P.; Gailer, M.; Buenaventura, T.; Kanda. N.; Jones, B. J.; M’Kadmi, Z.; Baneres, J.-L.; Marie, J.; Tomas, A.; Trauner, D.;* Hoffmann-Röder, A.,* Hodson, D. J.* ACS Cent. Sci. 2018, 4, 166–179.
"A Predictive Approach for the Optical Control of Carbonic Anhydrase II Activity" DuBay, K. H.; Iwan, K.; Osorio-Planes, L.; Geissler, P. L.; Groll, M.; Trauner, D.; Broichhagen, J. ACS Chem. Biol. 2018, 13, 793–800.
"SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand" Farrants, H.; Acosta Ruiz, A.; Gutzeit, V. A.; Trauner, D.; Johnsson, K.; Levitz, J.; Broichhagen, J. ACS Chem. Biol. 2018, 9, 2682-2688.
"Optical Control of a Biological Reaction–Diffusion System" Glock, P.; Broichhagen, J.; Kretschmer, S.; Blumhardt, P.; Mücksch, J.; Trauner, D.*; Schwille, P.* Ange. Chem. Int. Ed. 2018, 57, 2362-2366.
"Selective Synthesis of Divergolide I" Terwilliger, D.; Trauner, D. J. Am. Chem. Soc. 2018, 140, 2748-2751.
"Reversible Optical Control of F1F0-ATP Synthase Using Photoswitchable Inhibitors" Eisel, B.; Hartrampf, F. W. W.: Meier, T.;* Trauner, D.* FEBS Letters 2018, 592, 343–355.
"Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist" Donthamsetti, P. C.;Winter, N.; Schönberger, M.; Levitz, J.; Stanley, C.; Javitch, J. A.; Isacoff,E., Y.; Trauner, D. J. Am. Chem. Soc. 2017, 139, 18522-18535.
"Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor" Berry, M., H.; Holt, A.; Levitz, J.; Broichhagen, J.; Gaub, B., M.; Visel, M.; Stanley, C.; Aghi, K.; Kim, J., J.; Cao. K.; Kramer, R., H.; Trauner, D.; Flannery, J.; Isacoff, E., Y.; Nat. Communications 2017, 1862.
"PhoDAGs Enable Optical Control of Diacylglycerol-Sensitive Transient Receptor Potential Channels" Trese Leinders-Zufall, T.; Storch, U.; Bleymehl, K.; Mederos y Schnitzler, M.; Frank, J.: Konrad, D.; Trauner, D.; Gudermann, T.; Zufall, F. Cell Chemical Biology 2017, 25, 215-223.
"Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling" Westphal, M.; Schafroth, M.A.; Sarott, R.; Imhof, M.; Bold, C.; Leippe, P.; Dhopeshwarkar, A.; Grandner, J.; Katritch, V.; Mackie, K.; Trauner, D.;* Carreira, E. M.;* Frank, J. A.* J. Am. Chem. Soc. 2017, 139, 18206-18212.
"Specificity and Speed: Tethered Photopharmacology" Leippe, P.; Koehler-Leman, J.; Trauner, D. Biochemistry 2017, 56, 5214-5220.
"Optical Control of GPR40 Signaling in Pancreatic β-Cells" Frank, J. A.; Yushchenko, D.; Hine, N. N. F.; Duca, M.; Citir, M.; Broichhagen, J.; Hodson,* D. A.; Schultz, C.;* Trauner. D.* Chem.Sci. 2017, 8, 7604-7610.
"Total Synthesis of Crocagin A" Bihelovic, F.; Stichnoth, D.; Surup, F.; Müller, R.; Trauner, D. Angew. Chem. Int. Ed. 2017, 56, 13028-13031.
"Biomimetic Synthesis of Complex Flavonoids Isolated From Daemonorops ‘Dragon's Blood’" Schmid, M.; Trauner, D. Angew. Chem. Int. Ed. 2017, 56, 12332-12335.
"Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919-2" Cheng, B.; Müller, R.; Trauner, D. Angew. Chem. Int. Ed. 2017, 56, 12755-12759.
"Thiocarbonyl Ylide Chemistry Enables a Concise Synthesis of (±)-Hippolachnin A " Winter, N.; Trauner, D. J. Am. Chem. Soc., 2017, 139, 11706–11709.
"Total Synthesis of Lycopladine A and Carinatine A via a Base-Mediated Carbocyclization" Hartrampf, F.; Trauner, D. J. Org. Chem. 2017, 82, 8206-8212.
"Development of a Photoswitchable Antagonist of NMDA Receptors" Hartrampf, F. W. W.; Barber, D. M.; Gottschling, K.; Leippe, P.; Hollmann, M.; Trauner, D. Tetrahedron 2017, 73, 4905-4912.
"Asymmetric Synthesis of the Antiviral Diterpene Wickerol A" Liu, S.-A.; Trauner, D. J. Am. Chem. Soc. 2017, 239, 9491-9494.
"Wild-type Monomeric α-Synuclein Can Impair Vesicle Endocytosis and Aynaptic Fidelity via Tubulin Polymerization at the Calyx of Held " Eguchi, K.; Taoufiq, Z.; Thorn-Seshold, O.; Trauner, D.; Hasegawa, M.; Takahashi, T.; J. Neurosci. 2017, 37, 6043-6052.
"Structure and Biosynthesis of Crocagins: Polycyclic Posttranslationally Modified Ribosomal Peptides from Chondromyces crocatus". Viehrig, K.: Surup, F.: Volz, C.: Herrmann, J.: Abou Fayad, A.: Adam, S.; Köhnke, J.; Trauner, D.: Mūller, R. Angew. Chem. Int. Ed. 2017, 56, 7407-7410.
"Photopharmacological Control of Bipolar Cells Restores Visual Function in Blind Mice" Laprell, L.; Tochitsky, I.; Kaur, K.; Manookin, M. B.; Stein, M.; Barber, D. M.; Schoen, C.; Michalakis, S.; Biel, Kramer R. H.: Sumser, M.; Trauner, D.; * Van Gelder, R. N. * J. Clin. Invest. 2017, DOI:10.1172/JCI92156.
"Photoswitchable Inhibitor of a Glutamate Transporter" Cheng. B.; Shchepakin, B.; Kavanaugh, M.;* Trauner, D.* ACS Chem Neurosci. 2017, 8, 1668-1672.
"Light-Controlled Membrane Mechanics and Shape Transitions of Photoswitchable Lipid Vesicles" Pernpeintner, C.; Frank, J. A.; Urban, P.; Roeske, C. R.; Pritzl, S. D.; Trauner, D.;* Lohmüller, T.* Langmuir, 2017, 33, 4083-4089.
"Optical Control of a Receptor-linked Guanylyl Cyclase Using a Photoswitchable Peptidic Hormone" Podewin, T.; Broichhagen, J.; Frost, C.; Groneberg, D.; Ast, J.; Meyer-Berg, H.; Fine, N. H. F.; Friebe, A.; Zacharias, M.; Hodson, D. J.; Trauner, D.;* Hoffmann-Röder, A.*Chem. Sci. 2017, 8, 4644-4653.
"Dual Optical Control and Mechanistic Insights Into Photoswitchable Group II and III Metabotropic Glutamate Receptors" Levitz, J.; Broichhagen, J.; Leippe, P.; Konrad, D.; Trauner D: Isacoff, E. Y. Proc. Natl. Acad. Sci. USA 2017, 114, E3546–E3554.
"Selective Lithiation, Magnesiation and Zincation of Unsymmetrical Azobenzenes Using Continuous Flow" Ketels, M.; Konrad, D.; Karaghiosoff, K.; Trauner, D;* Knochel, P.* Org. Lett. 2017, 19, 1666–1669.
"Remote Control of Glucose Homeostasis in vivo Using Photopharmacology" Mehta, Z. B.; Johnston, N. R.; Nguyen-Tu, M.-S.; Broichhagen, J.; Schultz, P.; Larner, D. P.; Leclerc, I.; Trauner, D;* Rutter, G. A.;* Hodson, D. J.* Sci. Rep. 2017, 7, 291, DOI: 10.1038/s41598- 017-00397-0.
"Furans as Versatile Synthons: Total Syntheses of Caribenol A and Caribenol B" Hao, H.; Trauner. D. J. Am. Chem. Soc. 2017, 239, 12981-12986.
"Unravelling Photochemical Relationships Amongst Natural Products from Aplysia dactylomela" Matsuura, B. S.; Kölle, P.; de Vivie-Riedle, R.*; Trauner, D.*; Meier, R.* ACS Central Sci. 2017, 3, 39-46.
Open Access
"A Conia-Ene-Type Cyclization Under Basic Conditions Enables an Efficient Synthesis of (−)-Lycoposerramine R" Hartrampf, F.; Furukawa, T.; Trauner, D. Angew. Chem. Int. Ed.2017, 56, 893-896.
"Enantioselective Synthesis and Racemization of (–)-Sinoracutine" Volpin, G; Veprek, N. A.; Bellan, A. B.; Trauner. D. Angew. Chem. Int. Ed. 2017, 56, 897-901.
Optical Control of GIRK Channels Using Visible Light" Trads, J. B.; Burgstaller, J.; Laprell, L.; Konrad, D. B.; de la Osa de la Rosa, L.; Weaver, C. D.; Trauner. D.*; Barber, D.* Org. Biomol. Chem. 2017, 15, 76-81.
"Optical Control of Lipid Rafts with Photoswitchable Ceramides" Frank, J. A.; Franquelim, H. A.; Schwille, P.*; Trauner. D.* J. Am. Chem. Soc. 2016, 138, 12981-12986.
"Concise Asymmetric Synthesis of Kweichowenol A" Konrad, D. B.; Kicin, B.; Trauner, D. Synlett 2019, 30, 383–386.
"A Biomimetic Approach Toward Enterocin and Deoxyenterocin" Rizzo, A.; Mayer, R.; Trauner, D. JOC 2019, 84, 3, 1162–1175.
"Light-Controlled Lipid Interaction and Membrane Organization in Photolipid Bilayer Vesicles" Urban, P.; Pritzl, S., D.; Konrad, D., B.; Frank, J., A., Pernpeintner, C.; Roeske, C., R.; Trauner, D.; Lohmüller T. Langmuir 2018, 34, 13368–13374.
"Optical tools for understanding the complexity of β-cell signalling and insulin release" Frank, J. A.; Broichhagen, J.; Yushchenko, D., A.; Trauner, D.; Schultz, C.; Hodson, D., J. Nat. Rev. Endocrinol. 2018, 14, 721–737.
"Biomimetic Synthesis of (+)‐Aspergillin PZ" Reyes, J., Winter, N., Spessert, L., Trauner, D., Angew. Chem. Int. Ed. 2018, 57, 15587–15591.
"Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors" Durand-de Cuttoli, R.; Mondo,loni, S.; Marti, F.; Lemoine, D.; Nguyen, C.; Naude, J.; D'Izarnt-Gargas, T.; Pons, S.; Maskos, U.; Trauner, D.; Kramer, R., H.; Faure, P.; Mourot, A. eLife, 2018, e37487.
"Optical Control of a Delayed Rectifier and a Two-Pore Potassium Channel with a Photoswitchable Bupivacaine" Leippe, P.; Winter, N.; Sumser, M., P. ACS Chem. Neurosci. 2018, 9, 2886–2891.
“A Versatile Bis-Allylboron Reagent for the Stereoselective Synthesis of Chiral Diols” Hetzler, B. E.; Volpin, G.; Vignoni, E.; Petrovic, A. P.; Proni, G; Chunhua, T, H.; Trauner, D.* Angew. Chem. Int. Ed. 2018, 57, 14276–14280.
"Optical Control of L-Type Ca2+ Channels Using a Diltiazem Photoswitch" Fehrentz,T.; Huber, F. M. E.; Vrielink, N.; Bruegmann, T.; Frank, J. A.; Fine, N. H. F.; Malan, D.; Danzl, J. G.; Tikhonov, D. B.; Sasse, P.; Hodson, D. J.; Zhorov. B. S.; Klöcker, N.*; Trauner, D.* Nature Chem. Biol. 2018, 14, 764–767.
"In Vivo Photopharmacology" Hüll, K.; Morstein, J.; Trauner, D. Chem. Rev. 2018, 118, 10710–10747.
"Total Synthesis of (±)-Exotine B". Cheng, B.; Volpin, G.; Morstein, J.; Trauner., D. Org. Lett. 2018, 20, 4358–4361.
Open Access, ACS Editors' Choice
Toward (−)-Enterocin: An Improved Cuprate Barbier Protocol To Overcome Strain and Sterical Hindrance" Rizzo. A.; Trauner, D. Org. Lett. 2018, 20, 1841–1844.
"Total Synthesis of the Norhasubanan Alkaloid Stephadiamine"Hartrampf, N.; Winter, N.; Pupo, G.; Stoltz, B.; Trauner, D.* J. Am. Chem. Soc. 2018, 140, 8675–-8680.
"Azomethine Ylide Cycloaddition Approach toward Dendrobine: Synthesis of 5-Deoxymubironine C" Williams, B. M.; Trauner D. J. Org. Chem. 2018, 83, 3061–3068.
"Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology" Podewin, T.; Ast, J.; Broichhagen, J.; Fine, N. H. F.; Nateska, J.; Leippe, P.; Gailer, M.; Buenaventura, T.; Kanda. N.; Jones, B. J.; M’Kadmi, Z.; Baneres, J.-L.; Marie, J.; Tomas, A.; Trauner, D.;* Hoffmann-Röder, A.,* Hodson, D. J.* ACS Cent. Sci. 2018, 4, 166–179.
"A Predictive Approach for the Optical Control of Carbonic Anhydrase II Activity" DuBay, K. H.; Iwan, K.; Osorio-Planes, L.; Geissler, P. L.; Groll, M.; Trauner, D.; Broichhagen, J. ACS Chem. Biol. 2018, 13, 793–800.
"SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand" Farrants, H.; Acosta Ruiz, A.; Gutzeit, V. A.; Trauner, D.; Johnsson, K.; Levitz, J.; Broichhagen, J. ACS Chem. Biol. 2018, 9, 2682-2688.
"Optical Control of a Biological Reaction–Diffusion System" Glock, P.; Broichhagen, J.; Kretschmer, S.; Blumhardt, P.; Mücksch, J.; Trauner, D.*; Schwille, P.* Ange. Chem. Int. Ed. 2018, 57, 2362-2366.
"Selective Synthesis of Divergolide I" Terwilliger, D.; Trauner, D. J. Am. Chem. Soc. 2018, 140, 2748-2751.
"Reversible Optical Control of F1F0-ATP Synthase Using Photoswitchable Inhibitors" Eisel, B.; Hartrampf, F. W. W.: Meier, T.;* Trauner, D.* FEBS Letters 2018, 592, 343–355.
"Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist" Donthamsetti, P. C.;Winter, N.; Schönberger, M.; Levitz, J.; Stanley, C.; Javitch, J. A.; Isacoff,E., Y.; Trauner, D. J. Am. Chem. Soc. 2017, 139, 18522-18535.
"Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor" Berry, M., H.; Holt, A.; Levitz, J.; Broichhagen, J.; Gaub, B., M.; Visel, M.; Stanley, C.; Aghi, K.; Kim, J., J.; Cao. K.; Kramer, R., H.; Trauner, D.; Flannery, J.; Isacoff, E., Y.; Nat. Communications 2017, 1862.
"PhoDAGs Enable Optical Control of Diacylglycerol-Sensitive Transient Receptor Potential Channels" Trese Leinders-Zufall, T.; Storch, U.; Bleymehl, K.; Mederos y Schnitzler, M.; Frank, J.: Konrad, D.; Trauner, D.; Gudermann, T.; Zufall, F. Cell Chemical Biology 2017, 25, 215-223.
"Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling" Westphal, M.; Schafroth, M.A.; Sarott, R.; Imhof, M.; Bold, C.; Leippe, P.; Dhopeshwarkar, A.; Grandner, J.; Katritch, V.; Mackie, K.; Trauner, D.;* Carreira, E. M.;* Frank, J. A.* J. Am. Chem. Soc. 2017, 139, 18206-18212.
"Specificity and Speed: Tethered Photopharmacology" Leippe, P.; Koehler-Leman, J.; Trauner, D. Biochemistry 2017, 56, 5214-5220.
"Optical Control of GPR40 Signaling in Pancreatic β-Cells" Frank, J. A.; Yushchenko, D.; Hine, N. N. F.; Duca, M.; Citir, M.; Broichhagen, J.; Hodson,* D. A.; Schultz, C.;* Trauner. D.* Chem.Sci. 2017, 8, 7604-7610.
"Total Synthesis of Crocagin A" Bihelovic, F.; Stichnoth, D.; Surup, F.; Müller, R.; Trauner, D. Angew. Chem. Int. Ed. 2017, 56, 13028-13031.
"Biomimetic Synthesis of Complex Flavonoids Isolated From Daemonorops ‘Dragon's Blood’" Schmid, M.; Trauner, D. Angew. Chem. Int. Ed. 2017, 56, 12332-12335.
"Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919-2" Cheng, B.; Müller, R.; Trauner, D. Angew. Chem. Int. Ed. 2017, 56, 12755-12759.
"Thiocarbonyl Ylide Chemistry Enables a Concise Synthesis of (±)-Hippolachnin A " Winter, N.; Trauner, D. J. Am. Chem. Soc., 2017, 139, 11706–11709.
"Total Synthesis of Lycopladine A and Carinatine A via a Base-Mediated Carbocyclization" Hartrampf, F.; Trauner, D. J. Org. Chem. 2017, 82, 8206-8212.
"Development of a Photoswitchable Antagonist of NMDA Receptors" Hartrampf, F. W. W.; Barber, D. M.; Gottschling, K.; Leippe, P.; Hollmann, M.; Trauner, D. Tetrahedron 2017, 73, 4905-4912.
"Asymmetric Synthesis of the Antiviral Diterpene Wickerol A" Liu, S.-A.; Trauner, D. J. Am. Chem. Soc. 2017, 239, 9491-9494.
"Wild-type Monomeric α-Synuclein Can Impair Vesicle Endocytosis and Aynaptic Fidelity via Tubulin Polymerization at the Calyx of Held " Eguchi, K.; Taoufiq, Z.; Thorn-Seshold, O.; Trauner, D.; Hasegawa, M.; Takahashi, T.; J. Neurosci. 2017, 37, 6043-6052.
"Structure and Biosynthesis of Crocagins: Polycyclic Posttranslationally Modified Ribosomal Peptides from Chondromyces crocatus". Viehrig, K.: Surup, F.: Volz, C.: Herrmann, J.: Abou Fayad, A.: Adam, S.; Köhnke, J.; Trauner, D.: Mūller, R. Angew. Chem. Int. Ed. 2017, 56, 7407-7410.
"Photopharmacological Control of Bipolar Cells Restores Visual Function in Blind Mice" Laprell, L.; Tochitsky, I.; Kaur, K.; Manookin, M. B.; Stein, M.; Barber, D. M.; Schoen, C.; Michalakis, S.; Biel, Kramer R. H.: Sumser, M.; Trauner, D.; * Van Gelder, R. N. * J. Clin. Invest. 2017, DOI:10.1172/JCI92156.
"Photoswitchable Inhibitor of a Glutamate Transporter" Cheng. B.; Shchepakin, B.; Kavanaugh, M.;* Trauner, D.* ACS Chem Neurosci. 2017, 8, 1668-1672.
"Light-Controlled Membrane Mechanics and Shape Transitions of Photoswitchable Lipid Vesicles" Pernpeintner, C.; Frank, J. A.; Urban, P.; Roeske, C. R.; Pritzl, S. D.; Trauner, D.;* Lohmüller, T.* Langmuir, 2017, 33, 4083-4089.
"Optical Control of a Receptor-linked Guanylyl Cyclase Using a Photoswitchable Peptidic Hormone" Podewin, T.; Broichhagen, J.; Frost, C.; Groneberg, D.; Ast, J.; Meyer-Berg, H.; Fine, N. H. F.; Friebe, A.; Zacharias, M.; Hodson, D. J.; Trauner, D.;* Hoffmann-Röder, A.*Chem. Sci. 2017, 8, 4644-4653.
"Dual Optical Control and Mechanistic Insights Into Photoswitchable Group II and III Metabotropic Glutamate Receptors" Levitz, J.; Broichhagen, J.; Leippe, P.; Konrad, D.; Trauner D: Isacoff, E. Y. Proc. Natl. Acad. Sci. USA 2017, 114, E3546–E3554.
"Selective Lithiation, Magnesiation and Zincation of Unsymmetrical Azobenzenes Using Continuous Flow" Ketels, M.; Konrad, D.; Karaghiosoff, K.; Trauner, D;* Knochel, P.* Org. Lett. 2017, 19, 1666–1669.
"Remote Control of Glucose Homeostasis in vivo Using Photopharmacology" Mehta, Z. B.; Johnston, N. R.; Nguyen-Tu, M.-S.; Broichhagen, J.; Schultz, P.; Larner, D. P.; Leclerc, I.; Trauner, D;* Rutter, G. A.;* Hodson, D. J.* Sci. Rep. 2017, 7, 291, DOI: 10.1038/s41598- 017-00397-0.
"Furans as Versatile Synthons: Total Syntheses of Caribenol A and Caribenol B" Hao, H.; Trauner. D. J. Am. Chem. Soc. 2017, 239, 12981-12986.
"Unravelling Photochemical Relationships Amongst Natural Products from Aplysia dactylomela" Matsuura, B. S.; Kölle, P.; de Vivie-Riedle, R.*; Trauner, D.*; Meier, R.* ACS Central Sci. 2017, 3, 39-46.
Open Access
"A Conia-Ene-Type Cyclization Under Basic Conditions Enables an Efficient Synthesis of (−)-Lycoposerramine R" Hartrampf, F.; Furukawa, T.; Trauner, D. Angew. Chem. Int. Ed.2017, 56, 893-896.
"Enantioselective Synthesis and Racemization of (–)-Sinoracutine" Volpin, G; Veprek, N. A.; Bellan, A. B.; Trauner. D. Angew. Chem. Int. Ed. 2017, 56, 897-901.
Optical Control of GIRK Channels Using Visible Light" Trads, J. B.; Burgstaller, J.; Laprell, L.; Konrad, D. B.; de la Osa de la Rosa, L.; Weaver, C. D.; Trauner. D.*; Barber, D.* Org. Biomol. Chem. 2017, 15, 76-81.
"Optical Control of Lipid Rafts with Photoswitchable Ceramides" Frank, J. A.; Franquelim, H. A.; Schwille, P.*; Trauner. D.* J. Am. Chem. Soc. 2016, 138, 12981-12986.
Damijonaitis, A.; Barber, D. M.; Trauner, D. The Photopharmacology of Nicotinic Acetylcholine Receptors. Neurotransmitter 2016, 3, 1292.
"Optical Control of AMPA Receptors Using a Photoswitchable Quinoxaline-2,3-dione Antagonist" Barber, D. M.; Liu, S.-A.; Gottschling, K.; Sumser, M.; Hollmann, M.; Trauner, D. Chem.Sci. 2017, 8, 611-615.
Open Access
"Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose" Johnston, N. R.; Mitchell, R. K.; Haythorne, E.; Paiva Pessoa, M.; Semplici, F.; Ferrer, J.; Piemonti, L.; Marchetti, P.; Bugliani, M.; Bosco, D.; Berishvili, E.; Duncanson, P.; Watkinson, M.; Broichhagen, J.; Trauner, D.; Rutter, G. A.; Hodson, D. J. Cell Metab. 2016, 24, 389-401.
Open Access
"Photoswitchable Diacylglycerols Enable Optical Control of Protein Kinase C" Frank, J. A.; Yushchenko, D.; Hodson, D. A.; Lipstein, N.; Nagpal, J.; Rutter, G. A.; Rhee, J.-S.; Gottschalk, A.; Brose, N.; Schultz, C.; Trauner. D. Nature Chem. Biol. 2016, 12, 755-762.
"A Synthesis of (±)-Aplydactone" Meier, R., Trauner, D. Angew. Chem. Int. Ed. 2016, 55, 11251-11255.
Highlighted in Synfacts
"Allosteric Optical Control of a Class B G-Protein-Coupled Receptor”. Broichhagen, J.; Johnston, N. R.; von Ohlen, Y.;Meyer-Berg, H.; Jones, B. J.; Bloom, S. R.; Rutter, G. A.; Trauner. D.*;Hodson, D. J.* Angew. Chemie Int. Ed. 2016, 55, 5865-5868.
"A Family of Photoswitchable NMDA Receptors" Berlin, S.; Szobota, S.; Reiner, A.; Kienzler, M. A.; Guyon, A.; Trauner. D.; Isacoff. E. Y. eLife 2016, e12040, DOI: 10.7554/eLife.12040.
Open Access
"Synthesis of Redshifted Azobenzene Photoswitches via Late-Stage Functionalization" Konrad, D.; Frank, J. A.; Trauner, D. Chem. Eur. J. 2016, 22, 4364-4368.
“6-[6-(Pyridin-2-yl)-1,2,4,5-tetrazin-3-yl]pyridin-3-amine monohydrate” Broichhagen, J.; Klingl, Y. E.; Trauner, D.; Mayer, P. Acta Cryst. 2016, E72, 238-240.
Open Access
"Expedient Synthesis of Lycopalhine A" Williams. B., Trauner, D.* Angew. Chemie Int. Ed. 2016, 55, 2191-2194.
Highlighted in Synfacts
"Optical Control of Neuronal Activity Using a Light Operated GIRK-Channel Opener (LOGO)" Barber, D.; Schönberger, M.; Burgstaller, J.; Levitz, J.; Weaver, C. D.; Isacoff, E. Y.; Baier, H.; Trauner. D. Chem. Sci. 2016, 7, 2347-2352.
Open Access
"Synthetic Approaches Towards Alkaloids Bearing a-Tertiary Amines" Hager, A.; Vrielink, N.; Hager, D.; Lefranc, J.; Trauner, D. Nat. Prod. Rep. 2016, 33, 491-522.
"Restoring Light Sensitivity in Blind Retinae Using a Photochromic AMPA Receptor Agonist" Laprell, L.; Hüll, K.; Stawski, P.; Schön, C.; Michalakis, S.; Biel, M.; Sumser, M. P.; Trauner, D. ACS Chem. Neurosci. 2016, 7, 15-20.
Highlighted as Front Cover
"Inter-Kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway" Simon, S.; Schell, U.; Heuer, N.; Hager, D.; Albers, M. F.; Matthias, J.; Fahrnbauer, F.; Trauner, D.; Eichinger, L.; Hedberg, C.; Hilbi, H. PLOS Pathogens 2015, 11, e1005307.
"Optical Control of Insulin Secretion Using an Incretin Switch" Broichhagen, J.; Podewin T.; Meyer-Berg, H.; von Ohlen, Y.; Johnston, N. R.; Jones, B. J.; Bloom, S. R.; Rutter, G. A.; Hoffmann-Röder, A.*; Hodson, D. J. *; Trauner. D.* Angew. Chem. Int. Ed. 2015, 54, 15565-15569.
"A Highly Convergent and Biomimetic Total Synthesis of Portentol" Cheng, B.; Trauner, D.J. Am. Chem. Soc. 2015, 137, 13800-13803.
"Orthogonal Optical Control of a G Protein-Coupled Receptor With a SNAP-Tethered Photochromic Ligand" Broichhagen, J.; Damijonaitis, A.; Levitz, J.; Sokol, K. R.; Leippe, P.; Konrad, D.; Isacoff, E. Y.; Trauner, D. ACS Central Sci. 2015, 1, 383-393.
"Light-Dark Adaptation of Channelrhodopsin Involves Photoconversion Between the all-trans and 13-cis Retinal Isomers" Bruun, S.; Stoeppler, D.; Keidel. A.; Kuhlmann, U.; Luck, M.; Diehl, A.; Geiger M.A.; Woodmansee, D.; Trauner, D., Hegemann, P.; Oschkinat H.; Hildebrandt, P.; Stehfest, K. Biochemistry 2015, 54, 5389-5400.
"An Eight-Step Synthesis of Epicolactone Reveals its Biosynthetic Origin" Ellerbrock, P.; Armanino. N.; Ilg. M. K.; Webster, R.; Trauner, D. Nature Chemistry 2015, 7, 879-882.
Highlighted in Nature Chemistry and Synfacts
"Molecular Dynamics Investigation of Gluazo, a Photo-Switchable Ligand for the Glutamate" Guo, Y.; Wolter, T.; Kubař, T.; Sumser, M.; Trauner, D.; Elstner, M. PLoS One 2015, 10, e0135399.
"Optical Control of NMDA-Receptors With a Diffusible Photoswitch" Laprell, L.; Repak, E.; Franckevicius, V.; Hartrampf, F.; Terhag, J.; Hollmann. M.; Sumser, M.; Rebola, N., DiGregorio, D.*; Trauner, D.* Nature Commun. 2015, 6, 8076.
Open Access Article
"Richard Willstätter and the 1915 Nobel Prize in Chemistry" Trauner, D. Angew. Chem. Int. Ed. 2015, 54, 11910-11916.
"Azobenzene-Based Inhibitors of Human Carbonic Anhydrase II" Runtsch, L. S.; Barber, D. M.; Mayer, P.; Groll, M.; Trauner, D.; Broichhagen, J. Beilstein J. Org. Chem. 2014, 11, 1129-1135.
"Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death" Borowiak, M.; Nahaboo, W.; Reynders, M.; Nekolla, K.; Jalinot, P.; Hasserodt, J.; Rehberg, M.; Delattre, M.; Zahler, S.; Vollmar, A.; Trauner, D.*; Thorn-Seshold, O.* Cell 2015, 162, 403-411.
Highlights in EMBO Journal, Nat Chem Bio, Cell Previews, The Economist
"Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer" Schneider, L. S.; von Schwarzenberg, K.; Lehr, T.; Ulrich, M.; Kubisch- Dohmen, R.; Liebl, J.; Trauner, D.; Menche, D.; Vollmar, A. M. Cancer Res. 2015, 75, 2863-2874.
Evolution of a Unified Strategy for Complex Sesterterpenoids: Progress toward Astellatol and Total Synthesis of (−)-Nitidasin" Hog, D. T.; Huber, F. M. E.; Jiménez-Osés, G.*; Mayer, P.; Houk, K. N., Trauner, D.* Chem. Eur. J., 2015, 21, 13646-13665.
"A Roadmap to Success in Photopharmacology" Broichhagen, J.; Frank, J.A.; Trauner, D.Acc. Chem. Res., 2015, 48, 1947-1960.
Crystal Structure of (E)-1,2-Bis(4-bromo-2,6-difluorophenyl)diazene" Broichhagen, J.; Woodmansee, D. H.; Trauner, D.; Mayer, P. Acta Crystallographica Section E: Structure Reports Online 2015, 71, o459-o460.
"Photoswitchable Fatty Acids Enable Optical Control of TRPV1" Frank, J. A.; Moroni, M.; Moshourab, R.; Sumser, M.; Lewin, G. R.; Trauner, D. Nature Commun. 2015, 6, 7188.
"Molecular Aesthetics" Herausgegeben von Peter Weibel und Ljiljana Fruk" (Book Review) Trauner, D. Angew. Chemie Int. Ed. 2015, 54, 7074.
"Biomimetic Total Synthesis of Santalin Y" Strych, S.; Journot, G.; Pemberton, R.P.; Wang, S. C.; Tantillo, D.*, Trauner, D.* Angew. Chem. Int. Ed. 2015, 54, 5079-5083.
"AzoCholine Enables Optical Control of Alpha 7 Nicotinic Acetylcholine Receptors in Neural Networks" Damijonaitis, A.; Broichhagen, J.; Urushima, T.; Hüll, K.; Nagpal, J.; Laprell, L.; Schönberger, M.; Woodmansee, David; Rafiq, A.; Sumser, M.; Kummer, W.; Gottschalk, A.; Trauner, D. ACS Chem. Neurosci. 2015, 6, 701-707.
"A Red-Shifted Photochromic Sulfonylurea for the Remote Control of Pancreatic Beta Cell Function" Broichhagen, J.; Frank, J. A.; Johnston, N. R.; Mitchell, K.; Smid, K.; Marchetti, P.; Bugliani, M.; Rutter, G. A.; Trauner. D.*; Hodson, D.* Chem. Commun. 2015, 27, 6018- 6021.
"Calculated Nuclear Magnetic Resonance Spectra of Polytwistane and Related Hydrocarbon Nanorods" Maryasin, B.; Olbrich, M.; Trauner, D.*; Ochsenfeld, C.* J. Chem. Theory Comput. 2015, 11, 1020-1026.
"Synthetic Studies Toward Polytwistane Hydrocarbon Nanorods" Olbrich, M.; Mayer, P.; Trauner, D. J. Org. Chem., 2015, 80, 2042-2055.
Highlighted as Front Cover
"Long Wavelength Optical Control of Glutamate Receptor Ion Channels Using a Tetra- Ortho-Substituted Azobenzene Derivative" Rullo, A.; Reiner, A.; Reiter, A.; Trauner, D.; Isacoff, E. Y.; Woolley, G. A. Chem. Commun. 2014, 50, 14613-14615.
"Extraction of Photogenerated Electrons and Holes From a Covalent Organic Framework Integrated Heterojunction" Calik, M.; Auras, F.; Li, Y.; Salonen, L.; Bader, K.; Gill, I.; Handloser, M.; Medina, D.; Dogru, M.; Löbermann, L. M.; Trauner, Hartschuh, A.; D.; Bein, T. J. Am. Chem. Soc. 2014, 136, 51, 17802-17807.
"Synthetic Retinal Analogs Modify the Spectral and Kinetic Characteristics of Microbial Rhodopsin Optogenetic Tools" AzimiHashemi, N.; Erbguth, K.; Vogt, A.; Riemensperger, T; Rauch, E.; Woodmansee, D.; Nagpal, J.; Brauner, M.; Sheves, M.; Fiala, A.; Kattner, L.; Trauner, D.; Hegemann, P.; Gottschalk, A.; Liewald, J. F. Nature Commun. 2014, 5, 5810.
"Photochemical Formation of Intricarene" Stichnoth, D.; Kölle, P.; Kimbrough, T. J.; Riedle, E.; de Vivie-Riedle, R.; Trauner, D. Nature Commun. 2014, 5, 5597.
"Biomimetic Synthesis of the Calcineurin Phosphatase Inhibitor Dibefurin" Ellerbrock, P.; Armanino, N.; Trauner, D. Angew. Chem. Int. Ed. 2014, 53, 13414-13418.
"Optical Control of Insulin Release Using a Photoswitchable Sulfonylurea" Broichhagen, J.; Schönberger, M.; Frank, J.; Marchetti, P.; Bugliani, M.; Shapiro, A. M. J.; Trapp, S.; Rutter, G.; Hodson, D. J.*; Trauner, D.* Nature Commun. 2014, 5, 5116, DOI: 10.1038/ncomms6116.
"A Zinc Phthalocyanine-Based Periodic Mesoporous Organosilica Exhibiting Charge Transfer to Fullerenes" Auras, F.; Li, Y.; Löbermann, F.; Döblinger, M.; Schuster, J.; Peter, L. M.; Trauner, D.*; Bein, T.* Chem. Eur. J. 2014, 20, 14971-14975.
"The in vivo Chemistry of Photoswitched Tethered Ligands" Broichhagen, J.; Trauner, D.Curr. Opin. Chem. Biol. 2014, 21, 121-127.
"Total Synthesis of the Proposed Structure of Trichodermatide A" Myers. E.; Herrero- Gómez, E.; Baitinger, I.; Lachs, J.; Mayer, P.; Hanni, M.; Ochsenfeld, C.; Trauner, D.J. Org. Chem. 2014, 79, 9812-9817.
Highlighted in Synfacts
"A Pentasymmetric Open Channel Blocker for Cys-Loop Receptor Channels" Carta, V.; Pangerl, M.; Baur, R.; Puthenkalam, R.; Ernst, M.; Trauner, D.*; Sigel E.* PLoS ONE 2014, DOI: 10.1371/journal.pone.0106688.
"Relative Positioning of Classical Benzodiazepines to the γ2‐Subunit of GABA-A Receptors" Middendorp, S. J.; Hurni, E.; Stein, M.; Pangerl, M.; Trauner, D.; Sigel E. ACS Chem. Biol. 2014, 9, 1846-1853.
"Controlling Epithelial Sodium Channels With Light Using Photoswitchable Amilorides" Schönberger, M.; Althaus, M., Fronius, M.; Clauss, W., Trauner, D. Nature Chemistry 2014, 6, 712-719.
"The Total Synthesis of (–)-Nitidasin" Hog, D.; Huber. F.; Mayer, P.; Trauner, D. Angew. Chem. Int. Ed. 2014, 53, 8413-8517.
Highlighted in Synfacts
"Der Schattensammler. Die allerletzte Autobiografie. By Carl Djerassi (Book Review)"Angew. Chem. Int. Ed. Engl. 2014, 53, 2808.
"Development of a New Photochromic Ion Channel Blocker via Azologization of Fomocaine" Schönberger, M.; Damijonaitis, A.; Zhang, Z.; Nagel, D.; Trauner, D. ACS Chem. Neurosci. 2014, 5, 515-518.
"Development of an Iron(II)-Catalyzed Aerobic Catechol Cleavage and Biomimetic Synthesis of Betanidin" Guimond, G.; Mayer, P.; Trauner, D. Chem. Eur. J. 2014, 20, 9519-9523.
"Optical Control of Acetylcholinesterase with a Tacrine Photoswitch" Broichhagen, J.; Jurastow, I.; Iwan, K.; Kummer, W.; Trauner, D. Angew. Chem. Int. Ed. 2014, 53, 7657- 7660.
"Biomimetic Synthesis of (±)-Merochlorin B" Meier, R.; Strych, S.; Trauner, D. Org. Lett.2014, 16, 2634-2637.
"Ligand Photo-Isomerization Triggers Conformational Changes in iGluR2 Ligand Binding Domain" Wolter, T.; Steinbrecher, T.; Trauner, D.; Elstner, M. PLOS One 2014, 9, e97216.
"A Robust Route towards Functionalized Pyrrolizidines as Precursors for Daphniphyllum Alkaloids" Pangerl, M.; Höhlein, I.; Trauner, D. Synlett 2014, eFirst.
"Restoring Visual Function in Blind Mice With a Photoswitch That Exploits Electrophysiological Remodeling of Retinal Ganglion Cells" Tochitsky, I.; Polosukhina, A.; Degtyar, V. E.; Gallerani, N.; Smith, C. M.; Friedman, A.; Van Gelder, R. N.; Trauner, D.; Kaufer, D.; Kramer R. H. Neuron 2014, 81, 800-813.
"A Photochromic Agonist of μ-Opioid Receptors" Schönberger, M.; Trauner, D. Angew. Chem. Int. Ed. 2014, 53, 3264-3267.
"Polytwistane" Barua, S. R.; Quanz, H.; Olbrich, M.; Schreiner, P. R.; Trauner, D.; Allen, W.D. Chem. Eur. J. 2014, 20, 1638-1645.
"A Step Toward Polytwistane: Synthesis and Characterization of C2-Symmetric Tritwistane" Olbrich, M.; Mayer, P.; Trauner, D. Org. Biomol. Chem. 2014, 12, 108-112.
Highlighted in Synfacts
"Toward the Total Synthesis of Ansalactam A" Hager, A.; Kuttruff, C. A.; Herrero-Gomez, E.; Trauner, D. Tetrahedron Lett. 2014, 55, 59-62.
"Total Synthesis of Sandresolide B and Amphilectolide" Chen, I. T.; Baitinger, I.; Schreyer, L.; Trauner, D. Org. Lett. 2014, 16, 166-169.
"A Photoswitchable Neurotransmitter Analogue Bound to its Receptor" Reiter, A.; Skerra, A., Trauner, D.*; Schiefner, A.* Biochemistry 2013, 52, 8972-8974.
"Bilirubin in a New Light" Broichhagen, J.; Trauner, D. Angew. Chem. Int. Ed. 2013, 53, 13868-13070.
"Challenges and Opportunities for Optochemical Genetics" Isacoff, E.; Kramer, R.; Trauner, D. in Optogenetics, Hegemann, P., Sigrist, S. eds., De Gruyter 2013, pp. 35-46.
"A Red-Shifted, Fast-Relaxing Azobenzene Photoswitch for Visible Light Control of an Ionotropic Glutamate Receptor" Kienzler, M. A.; Reiner, A.; Trautman, E.; Yoo, S.; Trauner, D.*; Isacoff, E. Y.* J. Am. Chem. Soc. 2013, 135, 17683–17686.
"A Photoactive Porphyrin-Based Periodic Mesoporous Organosilica Thin Film" Li, Y.; Auras, F.; Löbermann, F.; Döblinger, M.; Schuster, J.; Peter, L. M.; Trauner, D.*; Bein, T.*J. Am. Chem. Soc. 2013, 135, 18513–18519.
"Total Synthesis of Herbicidin C and Aureonuclemycin: Impasses and New Avenues" Hager, D.; Paulitz, C.; Tiebes, J.; Mayer, P.; Trauner, D. J. Org. Chem. 2013, 78, 10784- 10801.
"Tetraphenylporphyrin Derivative Specifically Blocks Members of the Voltage-Gated Potassium Channel Subfamily Kv1" Hornig, S.; Ohmert, I.; Trauner, D.; Ader, C.; Baldus, M.; Pongs, O. Channels 2013, 7, 1-10.
"Toward the Total Synthesis of Divergolides C and D" Hager, A.; Kuttruff, C. A.; Hager, D.; Terwilliger, D. W.; Trauner, D. Synlett 2013, 24, 1915-1920.
"Intramolecular Vinyl Quinone Diels–Alder Reactions: Asymmetric Entry to the Cordiachrome Core and Synthesis of (−)-Isoglaziovianol" Löbermann, F.; Weisheit, L.; Trauner, D. Org. Lett. 2013, 15, 4324-4326.
"Biomimetic Synthesis of Santalin A, B and Santarubin A, B, the Major Colorants of Red Sandalwood" Strych, S.; Trauner, D. Angew. Chem. Int. Ed. 2013, 52, 9509-9512.
Synform: [DOI]
"Optical Control of TRPV1 Channels" Stein, M.; Breit, A.; Fehrentz, T.; Gudermann, T.; Trauner, D. Angew. Chem. Int. Ed. 2013, 52, 9845-9848
"Studies toward the Biomimetic Total Synthesis of (–)-PF-1018" Webster, R.; Gaspar, B.; Mayer, P.; Trauner, D. Org. Lett. 2013, 15, 1866-1869.
"Optical Control of Metabotropic Glutamate Receptors" Levitz, J.; Pantoja, C.; Gaub, B; Janovjak, H.; Reiner, A.; Hoagland, A.; Schoppik, D.; Kane, B.; Stawski, P.; Schier, A. F.; Trauner, D.*; Isacoff, E. Y.* Nat. Neurosci. 2013, 16, 507-516.
Optical Control of Calcium-Regulated Exocytosis" Izquierdo, M., Trauner, D., Llobet, A., Gorostiza, P. Biochim. Biophys. Acta 2013, 1830, 2853–2860.
"Characterization of a Diffusible Signaling Factor from Xylella Fastidiosa" Beaulieu, E. D.; Ionescu, M.; Chaterjee, S.; Yokota, K.; Trauner, D.; Lindow, S. mBio 2013, 4, e00539-12.
"Optical Modulation of Neurotransmission Using Calcium Photocurrents Through the Ion Channel LiGluR" Izquierdo-Serra, M.; Trauner, D.; Lobet, A.; Gorostiza, P. Frontiers. Mol. Neurosci. 2013, 6, doi: 10.3389/fnmol.2013.00003.
"A 1H-NMR Assay for Measuring the Photostationary states of Photoswitchable Ligands" Banghart, M., Trauner, D. Methods Mol. Biol. 2013, 995, 105-120.
"Mode of Cell Death Induction by Pharmacological Vacuolar H+-ATPase (V-ATPase) Inhibition" Von Schwarzenberg, K.; Wiedmann, R. M.; Zahler, S.; Trauner, D.; Vollmar, A. M. J. Biol. Chem. 2013, 288, 1385-1396.
